Abstract
Central nervous system cryptococcal infections usually manifests as meningitis, meningoencephalitis,
encephalitis or ventriculitis. Cryptococcal choroid plexus inflammation is a particularly
rare entity most often presenting with signs and symptoms of intracranial hypertension,
hydrocephalus or meningitis due to a delayed diagnosis. Herein we reported the case
of a 63-year-old immunocompetent woman with a history of temporal lobe epilepsy and
behavioral disorders. Magnetic resonance imaging (MRI) and fluorodeoxyglucose positron
emission tomographic (FDG-PET) images revealed atypical cryptococcal choroid plexitis
with surrounding bitemporal edema without features of meningitis, intraparenchymal
cryptococcoma or hydrocephalus. The patient underwent serial MRI and FDG-PET images
performed before and after antifungal therapy that caused a marked clinical improvement.
Our case also suggests a potential role of FDG-PET in the monitoring antifungal therapeutic
efficacy.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cryptococcal choroid plexitis an uncommon fungal disease. Case report and review.Can J Neurol Sci. 2009; 36: 117-122
- Cryptococcal choroid plexitis: rare imaging findings of central nervous system cryptococcal infection in an immunocompetent individual.Br J Radiol. 2010; 83: 14-17
- MRI findings of cerebral cryptococcosis in immunocompetent patients.J Med Imaging Radiat Oncol. 2011; 55: 52-57
- Intraventricular cryptococcoma successfully treated with liposomal amphotericin B and voriconazole: a case report.No Shinkei Geka. 2012; 40: 777-784
- CT of intracranial cryptococcosis.AJNR Am J Neuroradiol. 1990; 11: 139-142
- Choroid plexus infections: neuroimaging appearances of four cases.AJNR Am J Neuroradiol. 1992; 13: 374-378
- Intraventricular cryptococcal granuloma. Report of two cases.J Neurosurg. 1988; 68: 145-148
- Cryptococcal choroid plexitis as a mass lesion: MR imaging and histopathologic correlation.AJNR Am J Neuroradiol. 2002; 23: 273-276
- MRI features of choroid plexitis.Neuroradiology. 1998; 40: 303-307
- MRI of choroidal plexus involvement in intracranial cryptococcosis.J Comput Assist Tomogr. 1993; 17: 547-550
- EANM/SNMMI guideline for 18F-FDG use in inflammation and infection.J Nucl Med. 2013; 54: 647-658
Article info
Publication history
Published online: August 29, 2013
Accepted:
August 7,
2013
Received:
May 11,
2013
Identification
Copyright
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
