I read the paper by Igase et al. [
], conducting a cross-sectional study of 116 elderly first-time ischemic stroke patients. They were classified into three groups; 57 patients with deep or infratentorial cerebral microbleeds (CMBs), 17 patients with lobar CMBs, and 42 patients without CMBs. I have some concerns on their statistical procedures.
- Igase M.
- Kohara K.
- Igase K.
- Yamashita S.
- Fujisawa M.
- Katagi R.
- et al.
Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients.
J Neurol Sci. 2013; 325: 137-141
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- Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients.J Neurol Sci. 2013; 325: 137-141
- A modified approach to estimating sample size for simple logistic regression with one continuous covariate.Stat Med. 2010; 29: 97-107
- A simulation study of the number of events per variable in logistic regression analysis.J Clin Epidemiol. 1996; 49: 1373-1379
Published online: August 26, 2013
Accepted: August 5, 2013
Received: June 30, 2013
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.