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Letter to the Editor| Volume 334, ISSUE 1-2, P197, November 15, 2013

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The number of independent variables and events for multiple logistic regression analysis

Published:August 26, 2013DOI:https://doi.org/10.1016/j.jns.2013.08.004
      I read the paper by Igase et al. [
      • Igase M.
      • Kohara K.
      • Igase K.
      • Yamashita S.
      • Fujisawa M.
      • Katagi R.
      • et al.
      Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients.
      ], conducting a cross-sectional study of 116 elderly first-time ischemic stroke patients. They were classified into three groups; 57 patients with deep or infratentorial cerebral microbleeds (CMBs), 17 patients with lobar CMBs, and 42 patients without CMBs. I have some concerns on their statistical procedures.
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      References

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        • Kohara K.
        • Igase K.
        • Yamashita S.
        • Fujisawa M.
        • Katagi R.
        • et al.
        Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients.
        J Neurol Sci. 2013; 325: 137-141
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        A modified approach to estimating sample size for simple logistic regression with one continuous covariate.
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        A simulation study of the number of events per variable in logistic regression analysis.
        J Clin Epidemiol. 1996; 49: 1373-1379