The aim of this study was to identify factors associated with neuropsychological rehabilitation outcome in patients with multiple sclerosis (MS).
Ninety-eight relapsing–remitting MS patients received multimodal neuropsychological intervention (attention retraining, teaching compensatory strategies, psychoeducation, psychological support, and homework assignments) conducted once a week in 60-minute sessions during thirteen consecutive weeks. The evaluated factors included: 1) patient-related (baseline objective and subjective cognitive performance, mood, fatigue, as well as demographic factors); 2) illness-related (duration and severity of the disease); and 3) intervention-related factors (amount of computer-based attention exercises and homework assignments, therapist's evaluation of the benefit, and therapist).
Patient-related factors affected rehabilitation outcome, whereas illness- and intervention-related factors did not. The results showed that especially MS patients with male gender and more severe attentional deficits benefitted from the intervention.
Patient-related factors may affect neuropsychological rehabilitation outcome in MS.
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Published online: August 22, 2013
Accepted: July 31, 2013
Received in revised form: July 26, 2013
Received: April 18, 2013
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.