Research Article| Volume 334, ISSUE 1-2, P106-111, November 15, 2013

Patient-related factors may affect the outcome of neuropsychological rehabilitation in multiple sclerosis

Published:August 22, 2013DOI:



      The aim of this study was to identify factors associated with neuropsychological rehabilitation outcome in patients with multiple sclerosis (MS).


      Ninety-eight relapsing–remitting MS patients received multimodal neuropsychological intervention (attention retraining, teaching compensatory strategies, psychoeducation, psychological support, and homework assignments) conducted once a week in 60-minute sessions during thirteen consecutive weeks. The evaluated factors included: 1) patient-related (baseline objective and subjective cognitive performance, mood, fatigue, as well as demographic factors); 2) illness-related (duration and severity of the disease); and 3) intervention-related factors (amount of computer-based attention exercises and homework assignments, therapist's evaluation of the benefit, and therapist).


      Patient-related factors affected rehabilitation outcome, whereas illness- and intervention-related factors did not. The results showed that especially MS patients with male gender and more severe attentional deficits benefitted from the intervention.


      Patient-related factors may affect neuropsychological rehabilitation outcome in MS.


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