Abstract
Background
Cerebral microbleeds (CMBs) are the important indicators of cerebral small vessel
disease. However, it is still unclear whether endothelial dysfunction is involved
in CMBs. In this study, we performed a prospective study to investigate the correlation
between sE-selectin (soluble E-selectin) or adiponectin and the prevalence of CMBs.
Methods
We recruited 133 consecutive patients with first-ever ischemic stroke for this study.
Finally, 126 patients were analyzed. The number and presence of CMBs were detected
and evaluated on susceptibility-weighted magnetic resonance imaging within two weeks
after symptom onset. We assessed the serum levels of adiponectin and sE-selectin for
patients.
Results
CMBs were detected in 63 subjects (50%) within 126 patients and more prevalent in
mixed brain regions (55.6%). In binary logistic regression analysis, each 1SD-increase
in adiponectin level was significantly conversely associated with the prevalence of
CMBs after adjusting for age, sex and cardiovascular risk factors (OR = 0.55; 95% CI: 0.36–0.84); but sE-selectin was significantly positively associated
with the prevalence of CMBs (OR = 1.09; 95% CI: 1.02–1.15). Furthermore, partial correlation analyses showed that sE-selectin
remained significantly associated with and correlated conversely to adiponectin (r = −0.452, p = 0.001).
Conclusions
Endothelial injury may play a role in the pathogenesis of CMBs, and serum levels of
adiponectin and sE-selectin were closely related to CMBs. Adiponectin might be protective
for the prevalence of CMBs.
Keywords
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Article info
Publication history
Published online: August 29, 2013
Accepted:
July 25,
2013
Received in revised form:
July 24,
2013
Received:
April 15,
2013
Identification
Copyright
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
