Cross-reactivity of anti-epileptic drugs and its association with the HLA-B*1502 allele in Han Chinese patients

      Background: Recently, a few patient cases that were positive for the HLA-B*1502 allele have been reported to exhibit cross-reactivity to AEDs, suggesting that the HLA-B*1502 allele may contribute to the genetic susceptibility to the cross-reactivity of cutaneous adverse reactions (cADRs) to AEDs. However, there is limited convincing evidence, and this hypothesis is still controversial owing to the small sample sizes used in previous studies. Thus, it is necessary to further explore the potential association between the cross-reactivity of AEDs and the HLA-B*1502 allele.
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