Abstract
Edwin Bickerstaff and Philip Cloake reported in the 1950's three cases of reversible
encephalitis. The concept of antibody associated encephalitis had not been proposed
at the time they astutely recognized the importance of disease pattern recognition
and postulated a potential immune based mechanism. The syndrome defined by Bickerstaff
of progressive, external ophthalmoplegia and ataxia, with disturbance of consciousness
or hyperreflexia, has subsequently been associated with anti-GQ1b antibodies. Interestingly
one of the three original cases, a young woman who developed seizures, an eye movement
disorder and acute psychosis while awaiting ovarian cystectomy, has features that
may be more consistent with anti-NMDA receptor encephalitis.
Keywords
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Article info
Publication history
Published online: August 07, 2013
Accepted:
July 16,
2013
Received:
July 12,
2013
Identification
Copyright
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
