Edwin Bickerstaff and Philip Cloake reported in the 1950's three cases of reversible encephalitis. The concept of antibody associated encephalitis had not been proposed at the time they astutely recognized the importance of disease pattern recognition and postulated a potential immune based mechanism. The syndrome defined by Bickerstaff of progressive, external ophthalmoplegia and ataxia, with disturbance of consciousness or hyperreflexia, has subsequently been associated with anti-GQ1b antibodies. Interestingly one of the three original cases, a young woman who developed seizures, an eye movement disorder and acute psychosis while awaiting ovarian cystectomy, has features that may be more consistent with anti-NMDA receptor encephalitis.
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- Mesencephalitis and rhombencephalitis.Br Med J. 1951; 2: 77-81
- BMJ. 2008; 336: 839.2
- J Neuro Sci. 1969; 9: 398-399
- Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome.Ann Neurol. 1992; 31: 677e9
- An immunologic abnormality common to Bickerstaff's brain stem encephalitis and Fisher's syndrome.J Neurol Sci. 1993; 118: 83e7
- Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain–Barré syndrome.Brain. 2003; 126: 2279-2290
- Brain-stem encephalitis: further observations on a grave syndrome with benign prognosis.Br Med J. 1957; 1: 1384-1387
- Brainstem encephalitis and the syndrome of Miller Fisher: a clinical study.Brain. 1982; 105: 481-495
- Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies.Lancet Neurol. 2008; 7: 1091-1098
- Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin.Neurology. 2010; 75: 1735-1739
- Analysis of relapses in anti-NMDAR encephalitis.Neurology. 2011; 77: 996-999
Published online: August 07, 2013
Accepted: July 16, 2013
Received: July 12, 2013
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.