Abstract
Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple
sclerosis patients, participate in CNS innate and adaptive immunity, and have been
hypothesized to play an important role in multiple sclerosis progression. Experimental
autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte
glycoprotein peptide 35–55 provides a means by which to explore the genesis and disease
significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative
disorder that, in its' pathological features, strongly resembles multiple sclerosis.
Keywords
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References
Charcot JM. Lectures on the Diseases of the Nervous System. Second Series, Lecture VI (translated by G Sigerson), The New Sydenham Society, London, 1877.
- Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis.J Neurosci. 2009; 29: 14965-14979
- T cells become licensed in the lung to enter the central nervous system.Nature. 2012; 488: 675-679
- C-C chemokine receptor 6-regulated entry of Th-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.Nat Immunol. 2009; 10: 514-523
- Th17 lymphocytes traffic to the central nervous system independently of a4 integrin expression during EAE.J Exp Med. 2011; 208: 2465-2476
- Regional neural activation defines a gateway for autoreactive T cells to cross the blood–brain barrier.Cell. 2012; 148: 447-457
- Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.Eur J Immunol. 2004; 34: 1251-1261
- Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete Freund adjuvant.J Neuropathol Exp Neurol. 2010; 69: 372-385
- Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy.Trends Mol Med. 2001; 7: 115-121
- Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts.Brain. 2004; 127: 1009-1018
- The neuropathological basis of clinical progression in multiple sclerosis.Acta Neuropathol. 2011; 122: 155-170
- Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.J Immunol. 2011; 187: 1039-1046
- Th17 cells in autoimmune demyelinating disease.SeminImmunopathol. 2010; 32: 71-77
- In vivo imaging of partially reversible Th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.Immunity. 2010; 33: 424-436
- Antibody response in MOG35-55 induced EAE.J Neuroimmunol. 2011; 40–241: 28-33
- Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.Neurology. 2011; 77: 580-588
- Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitisoptica and related disorders.J Neuroinflamm. 2011; 8: 184
- Myelin-oligodendrocyte glycoprotein antibodies in adults with neuromyelitisoptica phenotype.Neurology. 2012; 79: 1273-1277
- Early neuronal and glial fate restriction of embryonic neural stem cells.J Neurosci. 2008; 28: 2551-2562
- Local generation of glia is a major astrocyte source in postnatal cortex.Nature. 2012; 484: 376-380
- Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.J Neurosci. 2011; 31: 11914-11928
- Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.Cell. 1999; 97: 703-716
- Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia.Glia. 2007; 55: 57-64
- Molecular outcomes of neuromyelitisoptica (NMO)-IgG binding to aquaporin-4 in astrocytes.Proc Natl Acad Sci USA. 2012; 109: 1245-1250
- Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.Nature. 2008; 451: 1076-1081
- Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse.J Neuroimmunol. 2012; 245: 32-38
- Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice.BMC Neurosci. 2009; 10: 94
- Live astrocytes visualized by green fluorescent protein in transgenic mice.DevBiol. 1997; 187: 36-42
- Gage FH (2000) Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord.J Neurosci. 2000; 20: 2218-2228
- Differentiation signals in the CNS: type-2 astrocyte development in vitro as a model system.Neuron. 1990; 5: 111-119
- Origin of new glial cells in intact and injured adult spinal cord.Cell Stem Cell. 2010; 7: 470-482
- The blood–brain barrier in health and chronic neurodegenerative disorders.Nature. 2008; 57: 178-201
- Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models.Immunol Rev. 2012; 248: 228-239
- Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis.FASEB J. 1993; 7: 592-600
- Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.J Exp Med. 2000; 192: 1075-1080
- Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis.J Exp Med. 2001; 193: 713-726
- Infiltrating monocytes trigger EAE progression but do not contribute to the resident microglia pool.Nature Neurosci. 2011; 14: 1142-1149
- Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity – a tale of conflict and conundrum.Neuropathol Appl Neurobiol. 2010; 36: 368-387
- Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation.Nature Med. 2005; 11: 966-972
- Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions.J Neurosci. 2011; 31: 4504-4510
- Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis.Glia. 1997; 20: 79-85
- Altered expression of glutamate transporters in experimental autoimmune encephalomyelitis.J Neuroimmunol. 2002; 125: 170-178
- GluR2-free alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors intensify demyelination in experimental autoimmune encephalomyelitis.J Neurochem. 2007; 102: 1064-1070
- Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors.Ann Neurol. 2009; 65: 160-166
- Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development.J Neurosci. 2012; 32: 639-645
- Astrocytes are active players in cerebral innate immunity.Trends Immunol. 2007; 28: 138-145
- Transgenic inhibition of astroglial NF-B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation.J Immunol. 2009; 182: 2628-2640
- CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes.Mol Ther. 2012; 20: 1338-1348
- Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration.J Exp Med. 2012; 209: 521-535
- Gp130-dependentastrocytic survival is critical for control of autoimmune central nervous system inflammation.J Immunol. 2011; 186: 6521-6531
Article info
Publication history
Published online: January 07, 2013
Accepted:
December 10,
2012
Received in revised form:
December 5,
2012
Received:
September 27,
2012
Footnotes
☆Supported by grants from Shriners Hospitals for Children, the National Multiple Sclerosis Foundation, US Army Medical Research, and NINDS.
☆☆Dedication: To Bob Lisak, who introduced DP to neuroimmunology during commutes to and from the University of Pennsylvania.
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
