Abstract
Paraoxonase 1 (PON1) activity and metabolic syndrome traits were evaluated in 169
demented patients (81 recognized as AD, 32 as VaD, 56 as MD) and in 64 control individuals.
Paraoxonase activity was determined spectrophotometrically using phenyloacetate as
substrate. Metabolic syndrome was recognized according to AHA/NHLBI criteria.
In the whole group with dementia significant positive correlation between PON1 activity/HDL
cholesterol ratio (i.e. HDL corrected PON1 activity) and insulin level as well as
HOMA IR index, was observed. The multivariate analysis showed that the PON1/HDL-C
ratio was also significantly positively associated with the presence of metabolic
syndrome (with insulin resistance as a major underlying trait) both in dementia and
in control group. High insulin level and HOMA-IR are considered to be the traits of
insulin resistance. It has however to be taken into account that they both could also
depend on insulin production and release which, as was recently stated in cell experiments,
are enhanced by PON1. The observed positive correlation suggests an advantageous role
of the enzyme in metabolic syndrome influence on dementia development.
Keywords
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Article info
Publication history
Published online: November 26, 2012
Accepted:
November 1,
2012
Received:
April 27,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.