Abstract
Nonmotor symptoms (NMSs) commonly occur in Parkinson's disease (PD). This study sought
to explore the domains of NMSs that are more closely related to PD using nonmotor
symptoms scale (NMSS), through a quantitative comparison of NMSs' prevalence and NMSS
scores of PD patients with normal controls, and clinical implications. We performed
a prospective case–control study on PD patients (n=131) and age- and gender-matched normal controls (n=129). We compared NMSs' prevalence and NMSS scores of the PD patients with those of
normal controls, and obtained the ratio to identify the domains that were more closely
related to PD than normal aging using the NMSS. NMSs are very common among normal
elderly as well as PD patients. The domains with the highest ratio of NMSs' prevalence
and NMSS scores between the patient and control groups were the miscellaneous, perceptual
problems/hallucinations, and sexual function. These three domains were found to be
most closely related to PD. NMSs with higher prevalence in PD patients do not always
relate more to PD. As NMSs in PD can also commonly occur among the normal elderly,
the NMS prevalence should be interpreted with extreme caution. To properly manage
the NMSs in PD, it should be kept in mind that avoiding the overestimation of NMSs
as part of PD is as important as their early recognition in PD.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Nonmotor fluctuation in Parkinson's disease.Neurology. 2002; 59: 408-413
- The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease.Mov Disord. 2009; 24: 1641-1649
- Nonmotor off symptoms in Parkinson's disease.J Korean Med Sci. 2009; 24: 311-314
- Non-motor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease.Mov Disord. 2010; 25: 2740-2746
- The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease.Mov Disord. 2011; 26: 399-406
- The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study.Mov Disord. 2007; 22: 1901-1911
- Sleep complaints among elderly persons: an epidemiologic study of three communities.Sleep. 1995; 18: 425-432
- Prevalence of lower gastrointestinal symptoms and associated consultation behavior in a British elderly population determined by face-to-face interview.Br J Gen Pract. 2000; 50: 798-802
- A study of sexuality and health among older adults in the United States.N Engl J Med. 2007; 357: 762-774
- The prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: a population-based study.Arch Gen Psychiatry. 2008; 65: 1193-1198
- Do nonmotor symptoms in Parkinson's disease differ from normal aging?.Mov Disord. 2011; 26: 2110-2113
- Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.J Neurol Neurosurg Psychiatry. 1992; 55: 181-184
- International multicenter pilot study of the first comprehensive self completed non motor symptoms questionnaire for Parkinson's disease: the NMSQuest study.Mov Disord. 2006; 21: 916-923
- Nonmotor symptoms of Parkinson's disease: prevalence and awareness of patients and families.Parkinsonism Relat Disord. 2008; 14: 286-290
- Quantitation of non-motor symptoms in Parkinson's disease.Eur J Neurol. 2008; 15: 2-7
- International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease.Neurology. 2009; 73: 1584-1591
Article info
Publication history
Published online: October 29, 2012
Accepted:
October 11,
2012
Received in revised form:
September 11,
2012
Received:
June 26,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
