Abstract
Background
Micro and macrovascular disease is the most frequent cause of morbidity and mortality
of the patients with diabetes mellitus. The resent investigations have pointed out
the relationship between endothelial dysfunction and the progression of these diabetic
complications, suggesting the crucial role of nitric oxide, vasodilator molecule of
endothelial origin, in these events, including diabetic symmetric polyneuropathy.
Material and methods
The present study encompassed 100 individuals with diabetes mellitus type II and diabetic
distal symmetric polyneuropathy (DSP). Nitrate+nitrite concentration, 3-nitrotyrosine, S-nitrosothiols, ADMA and SDMA levels and
arginase activity were determined compared to the control group consisted of 50 age
and sex matched voluntary blood donors.
Results
NO2+NO3 concentrations, as well as 3-nitrotyrosine, S-nitrosothiol, ADMA and SDMA levels
were significantly higher in patients with DSP compared to the control group. Plasma
arginase activity in the patients with diabetic DSP was significantly lower compared
to the values in plasma of control subjects.
Conclusion
The obtained results confirmed that nitrate+nitrite, 3-nitrotyrosine, S-nitrosothiols, ADMA, SDMA and arginase activity determination
in plasma of patients with diabetic DSP could be useful in monitoring the disease
development and in assesing the therapy effects.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Diabetes, other risk factors, and 12 yr cardiovascular mortality for men screened in the multiple risk factor intervention trial.Diabetes Care. 1999; 316: 434-444
- Features of endothelial dysfunction in early diabetic neuropathy.Lancet. 1989; II: 461-463
- Endothelial function in health and disease: new insights into the genesis of cardiovascular disease.Am J Med. 1998; 105: 32s-39s
- Dislipoproteinemia hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: as hypothesis.Atherosclerosis. 1998; 141: 17-30
- Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutic strategies.Curr Med Chem. 2005; 12: 267-275
- Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice.Exp Neurol. 2007; 205: 425-436
- Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage.Nature. 2000; 404: 787-790
- Endothelial dysfunction in diabetes.Br J Pharmacol. 2000; 130: 963-974
- Oxidative stress and diabetic vascular complications.Diabetes Care. 1996; 19: 257-267
- Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited.Diabetes. 2005; 54: 3435-3441
- Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic kidney and high-glucose-exposed human mesangial cells.Free Radic Biol Med. 2006; 40: 1454-1465
- Longterm glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes.J Clin Endocrinol Metab. 2009; 94: 2751-2756
- Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).Lancet. 1998; 352: 837-853
- Hyperglycemia and cardiovascular disease in type 2 diabetes.Diabetes. 1999; 48: 937-942
- Semiautomated measurement of nitrate in biological fluids.Clin Chem. 1998; 44: 679-681
- Early diagnosis of myocardial infarction by arginase activity determination.Clin Chim Acta. 1975; 60: 355-361
- Effect of thiol status on nitric oxide metabolism in the circulation.Arch Biochem Biophys. 1997; 341: 186-192
- Detection of S-nitrosothiols in biological fluids: a comparison among the most widely applied methodologies.J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 851: 124-139
- Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and others biological samples by high-performance liquid chromatography.Anal Biochem. 2002; 303: 131-137
- Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes.Eur J Nutr. 2012; https://doi.org/10.1007/s00394-012-0404-7
- Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.J Clin Invest. 2001; 108: 1341-1348
- Mechanisms of hyperglycemic damage in diabetes.Atlas of Diabetes. 2012https://doi.org/10.1007/978-1-4614-1028-7_10
- Vascular targets of redox signalling in diabetes mellitus.Diabetologia. 2002; 45: 476-494
- Nitric oxide synthases: regulation and function.Eur Heart J. 2012; 33: 829-837
- Diabetic endothelial dysfunction: the role of poly(ADP-ribose)polymerase activation.Nat Med. 2001; 7: 108-113
- New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy.Diabetes Care. 2003; 5: 1589-1596
- Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage.J Cardiovasc Pharmacol. 2000; 36: 182-187
- Acute hyperglycemia induced an oxidative stress in healthy subjects (letter).J Clin Invest. 2001; 108: 635-636
- New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-α.Endocrinology. 2010; 151: 2547-2555
- Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection.Neurochem Res. 2010; 35: 336-342
- Cytokine profile of peripheral blood in type 2 diabetes mellitus patients with diabetic retinopathy.Ann Clin Lab Sci. 2008; 38: 361-367
- S-nitrosylation in health and disease.Trends Mol Med. 2003; 9: 160-168
- Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes.Diabetes. 2012; https://doi.org/10.2337/db12-0224
- The total antioxidative capacity in plasma of patients with diabetes mellitus II and distal symmetric polyneuropathy.Mil. Med. Pharm. J. Serbia. 2008; 65 (In Serbian): 663-669
- Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion.Circ Res. 2004; 94: 559-565
- Diabetes-induced vascular dysfunction involves arginase I.Am J Physiol Heart Circ Physiol. 2012; 302: H159-H166
- Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.J Clin Biochem Nutr. 2012; 51: 68-75
- Arginine metabolism: nitric oxide and beyond.Biochem J. 1998; 336: 1-17
- Role of neuropathy and plasma nitric oxide in recurrent neuropathic and neuroischemic diabetic foot ulcers.Wound Repair Regen. 2001; 9: 353-359
- Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production.PLoS One. 2012; 7: e42038https://doi.org/10.1371/journal.pone.0042038
- Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease — possible candidates for paradoxical epidemiology?.Amino Acids. 2006; 30: 225-232
- Dimethylarginines in complicated type 1 diabetes: roles of insulin, glucose, and oxidative stress.Free Radic Biol Med. 2009; 47: 307-311
- l-Arginine and cardiovascular system.Pharmacol Rep. 2005; 57: 14-22
- Multifactorial risk factor intervention in patients with type 2 diabetes improves arginine bioavailability ratios.Diabet Med. 2012; 29: e365-e368
Article info
Publication history
Published online: October 26, 2012
Accepted:
September 25,
2012
Received in revised form:
September 19,
2012
Received:
July 19,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
