Abstract
Objectives
To assess the efficacy and safety of istradefylline as an adjunct to levodopa in patients
with Parkinson's Disease (PD).
Methods
In this study, we searched the Cochrane Library, MEDLINE, Embase, China Academic Journal
Full-text Database (CNKI), China Biomedical Literature Database (CBM), Chinese Scientific
Journals Database (VIP), and Wanfang Database. The quality of included studies was
strictly evaluated. Data analyses were performed by the Cochrane Collaboration's RevMan5.0
software.
Results
Five randomized controlled trials (RCTs) were included. The result showed a significant
reduction of the awake time per day spent in the OFF state and improvement of the
Unified Parkinson's Disease Rating Scale (UPDRS) Part III in the ON state when receiving
istradefylline compared with patients receiving placebo. There was no significant
difference between the istradefylline 20 mg and the istradefylline 40 mg groups in the UPDRS Part III in the ON state (WMD=1.27, 95% CI [−0.40, 2.95]). The results showed significant differences in dyskinesia (RR=1.63, 95% CI [1.16, 2.29]) compared to istradefylline 40 mg with placebo. There was no significant statistical difference with regard to other
adverse events.
Conclusions
The present study showed that istradefylline is safe and effective as an adjunct to
levodopa in patients with PD. Future large-scale, higher-quality, long-treatment,
and placebo-controlled trials are needed.
Keywords
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Article info
Publication history
Published online: October 22, 2012
Accepted:
August 30,
2012
Received in revised form:
August 27,
2012
Received:
May 31,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
