Advertisement

Sexual dysfunction ın multiple sclerosis: Gender differences

Published:October 17, 2012DOI:https://doi.org/10.1016/j.jns.2012.08.019

      Abstract

      Purpose

      To assess the frequency and nature of sexual dysfunction in multiple sclerosis (MS) patients and to investigate the relationships of SD with clinical, demographic and psychosocial factors by comparing MS patients with and without SD.

      Methods

      Eighty-nine patients were included, 45 males and 44 females, aging an average of 37.4±8.6 years (range:21–56). We applied Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) and Arizona Sexual Experiences Scale (ASEX) to all patients. Disability was evaluated with the expanded disability status scale (EDSS).

      Results

      60.7% (n=54) of patients reported SD according to MSISQ scores. Women exhibited significantly higher MSISQ scores than men (42.6±12.9 and 36.6±13.3, respectively; P=0.034). Women (7.9%) also reported to experience sexual arousal difficulties significantly more than men (1.1%) (P=0.024) according to ASEX. The patients were classified into three MSISQ-19 subscales, Primary, Secondary and Tertiary SD. The most common reported dimension of SD was secondary (32.5%, n=41). In this dimension of SD, patients mostly complained of pain-burning, memory-concentration problems and bowel symptoms. A significant relationship was found between Secondary SD and both EDSS score and disease duration (r=0.34 p=0.001 and r=0.21 p=0.042, respectively). Tertiary SD was also associated with EDSS score (r=0.23 p=0.03).

      Conclusion

      Sexual Dysfunction, a frequent problem for MS patients, is associated with gender. Women reported more SD than men. Secondary SD symptoms were the most common complaints for both men and women. Nonetheless women had more secondary SD symptoms than men. The emotional dimension of SD is related with disability.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Dupont S.
        Multiple sclerosis and sexual functioning — a review.
        Clin Rehabil. 1995; 9: 135-141
        • Vas J.
        Sexual impotence and some autonomic disturbances in men with multiple sclerosis.
        Acta Neurol Scand. 1969; 45: 166-182
        • Barak Y.
        • Achiron A.
        • Elizur A.
        • Gabbay U.
        • Noy S.
        • Sarova-Pinhas I.
        Sexual dysfunction in relapsing-remitting multiple sclerosis: magnetic resonance imaging, clinical and psychological correlates.
        J Psychiatry Neurosci. 1996; 21: 255-258
        • Demirkiran M.
        • Sarica Y.
        • Uguz S.
        • Yerdelen D.
        • Aslan K.
        Multiple sclerosis patients with and without sexual dysfunction: are there any differences?.
        Mult Scler. 2006; 12: 209-214
        • Lundberg P.O.
        Sexual dysfunction in female patients with multiple sclerosis.
        Int Rehabil Med. 1981; 3: 32-34
        • Valleroy M.L.
        • Kraft G.H.
        Sexual dysfunction in multiple sclerosis.
        Arch Phys Med Rehabil. 1984; 65: 125-128
        • Foley F.W.
        • Iverson J.
        Sexuality and multiple sclerosis.
        in: Kalb R.C. Scheinberg L.C. Multiple sclerosis and the family. Demos, New York1992: 63-82
        • Foley F.W.
        • LaRocca N.G.
        • Sanders A.S.
        • Zemon V.
        Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis.
        Mult Scler. 2001; 7: 417-421
        • Sanders A.S.
        • Foley F.W.
        • LaRocca N.G.
        • Nicholas G.
        • Zemon V.
        The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19).
        Sex Disabil. 2000; 18: 3-24
        • Zorzon M.
        • Zivadinov R.
        • Bosco A.
        • Bragadin L.M.
        • Moretti R.
        • Bonfigli L.
        • et al.
        Sexual dysfunction in multiple sclerosis: a case–control study. I. Frequency and comparison of groups.
        Mult Scler. 1999; 5: 418-427
        • Zivadinov R.
        • Zorzon M.
        • Bosco A.
        • Bragadin L.M.
        • Moretti R.
        • Bonfigli L.
        • et al.
        Sexual dysfunction in multiple sclerosis: II. Correlation analysis.
        Mult Scler. 1999; 5: 428-431
        • Polman C.H.
        • Reingold S.C.
        • Edan G.
        • Filippi M.
        • Hartung H.P.
        • Kappos L.
        • et al.
        Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”.
        Ann Neurol. 2005; 58: 840-846
        • Kurtzke J.F.
        Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).
        Neurology. 1983; 33: 1444-1452
        • McGahuey C.A.
        • Gelenberg A.J.
        • Laukes C.A.
        • Moreno F.A.
        • Delgado P.L.
        • McKnight K.M.
        • et al.
        The Arizona Sexual Experience Scale (ASEX): reliability and validity.
        J Sex Marital Ther. 2000; 26: 25-40
        • Lottman P.E.M.
        • Jongen P.J.H.
        • Rosier P.F.W.M.
        • Meuleman E.J.H.
        Sexual dysfunction in men with multiple sclerosis: A comprehensive pilot-study into etiology.
        Int J Impot Res. 1998; 10: 233-237
        • McCabe M.P.
        Relationship functioning and sexuality among people with multiple sclerosis.
        J Sex Res. 2002; 39: 302-309
        • Hutler B.M.
        • Lundberg P.O.
        Sexual function in women with advanced multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 1995; 59: 83-86
        • Nordvedt M.W.
        • Riise T.
        • Frugård J.
        • Mohn J.
        • Bakke A.
        • Skår A.B.
        • et al.
        Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five yeras afetr diagnosis.
        Mult Scler. 2007; 13: 106-112
        • Tepavcevic D.K.
        • Kostic J.
        • Basuroski I.D.
        • Stojsavljevic N.
        • Pekmezovic T.
        • Drulovic J.
        The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis.
        Mult Scler. 2008; 14: 1131-1136
        • Gruenwald I.
        • Vardi Y.
        • Gartman I.
        • Juven E.
        • Sprecher E.
        • Yarnitsky D.
        • et al.
        Sexual dysfunction in females with multiple sclerosis: quantitative sensory testing.
        Mult Scler. 2007; 13: 95-105
        • Tzortzis V.
        • Skriapas K.
        • Hadjigeorgiou G.
        • Mitsogiannis I.
        • Aggelakis K.
        • Gravas S.
        • et al.
        Sexual dysfunction in newly diagnosed multiple sclerosis women.
        Mult Scler. 2008; 14: 561-563