Abstract
The concept and diagnosis for mixed dementia is not simple, since it is difficult
to identify the type and regions of cerebrovascular disease (CVD) responsible for
causing dementia. An investigation is needed to confirm the presence of mixed dementia,
those who met the criteria for Alzheimer's disease (AD) and those for vascular dementia
(VaD). According to the community-based stroke, dementia, and bed-confinement prevention
in Kurihara, northern Japan (Kurihara Project), the prevalence of dementia and dementing
diseases was surveyed in 2008–2010. Five hundred and ninety people finally agreed
to participate (47.0%), and 73 (12.4%) people were diagnosed with dementia according
to the DSM-IV. Using MRI, intensive evaluations on CVDs were performed for the 49
dementia patients associated with CVDs (mixed dementia, VaD, and AD with CVD). For
the mixed dementia group, all had left subcortical strategic CVDs. These included
the caudate head and thalamus. For the VaD group, all patients had at least cortical
CVDs or subcortical strategic CVDs. The AD with CVD group had non-strategic CVDs in
cortical, subcortical, or other areas in 5 or 6 patients each. Two extreme concepts
regarding CVD and dementia are possible. One is that there is no concept for mixed
dementia or VaD. An alternative is that the vascular factor should be considered as
primary. Our data showed an importance of cortical and subcortical “strategic” areas,
the latter included thalamus and caudate head.
Keywords
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Article info
Publication history
Published online: August 07, 2012
Accepted:
July 19,
2012
Received in revised form:
June 2,
2012
Received:
January 27,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
