While evidence suggests that lobar intracerebral haemorrhage (ICH) is linked with
dementia and cognitive impairment, the association between cognition and mortality
risk from ICH is unclear.
To examine the association between dementia or cognitive impairment and short- and
medium-term mortality post ICH.
Patients with primary ICH were classified into lobar and non-lobar ICH using radiological
criteria. Patients' characteristics and radiological measures were collected at the
baseline along with history of dementia and cognitive impairment. Mortality risks
at 7, 30, 60, and 90 days were assessed using multiple logistic regression adjusting for potential confounders
identified as significant associates in univariate models.
A total of 136 patients (males 50%, mean age 77 years, SD 10) were included in this study. Out of 53 (39%) patients with lobar ICH
47 (89%) were classified as having possible and 6 (11%) as probable cerebral amyloid
angiopathy (CAA). In lobar ICH the prevalence of history of dementia or cognitive
impairment, confusion at presentation, previous ICH, multiple haemorrhages, and initial
haematoma volume were significantly higher (p<0.05). In lobar ICH the significant mortality predictors (p<0.05) were history of dementia or cognitive impairment (90 days), prior antiplatelet use (60 and 90 days), initial haematoma volume (60 days), male sex (30 and 60 days), age (30, 60, 90 days), and low Glasgow Coma Scale (GCS) (7 and 30 days). In non-lobar ICH prior use of anticoagulation, initial haematoma volume, low
GCS and age were significant mortality predictors (p<0.05).
A history of dementia or cognitive impairment is more common in lobar CAA-related
ICH and it is a medium-term mortality predictor in lobar ICH but not in deep non-lobar