Abstract
Depression is frequently associated with Parkinson disease (PD) but neural basis is
still unclear. In previous studies white matter changes present as signal hyperintesities
on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated
with depressive symptomatology. In this study we investigated whether WMHs were associated
with depression in PD patients with disease onset above the age of 60. Thirty-four
patients, with (PD-D) and 25 without depression (PD-nD), and 30 healthy age- and sex-matched
controls were analyzed using the Scheltens visual rating scale. Cerebrovascular risk
factors were similar across groups. Comparing controls and PD patients as a group
there were no differences in WMHs in any examined regions. However, PD-D group had
more common frontal WMHs although WMHs score didn't rich statistical significance.
The same came true for total deep white matter changes comparing those two groups.
In addition PD-D group had a significantly higher score for periventricular regions
WMHs comparing with both PD-nD group and controls.PD-D group had significantly higher
WMHs scores BG regions when compared to controls. The only significance in multivariate
analyses was shown for periventricular WMHs total score explaining the 39% of the
variance in the depressive score. Our findings suggest that WMH in the deep white
matter may contribute to depression in PD.
Keywords
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Article info
Publication history
Published online: August 06, 2012
Accepted:
July 10,
2012
Received in revised form:
July 1,
2012
Received:
February 13,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
