Advertisement

White matter lesions and depression in patients with Parkinson's disease

Published:August 06, 2012DOI:https://doi.org/10.1016/j.jns.2012.07.021

      Abstract

      Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investigated whether WMHs were associated with depression in PD patients with disease onset above the age of 60. Thirty-four patients, with (PD-D) and 25 without depression (PD-nD), and 30 healthy age- and sex-matched controls were analyzed using the Scheltens visual rating scale. Cerebrovascular risk factors were similar across groups. Comparing controls and PD patients as a group there were no differences in WMHs in any examined regions. However, PD-D group had more common frontal WMHs although WMHs score didn't rich statistical significance. The same came true for total deep white matter changes comparing those two groups. In addition PD-D group had a significantly higher score for periventricular regions WMHs comparing with both PD-nD group and controls.PD-D group had significantly higher WMHs scores BG regions when compared to controls. The only significance in multivariate analyses was shown for periventricular WMHs total score explaining the 39% of the variance in the depressive score. Our findings suggest that WMH in the deep white matter may contribute to depression in PD.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Reijnders J.S.
        • Ehrt U.
        • Weber W.E.
        • Aarsland D.
        • Leentjens A.F.
        A systematic review of prevalence studies of depression in Parkinson's disease.
        Mov Disord. 2008; 23: 183-189
        • Schrag A.
        Quality of life and depression in Parkinson's disease.
        J Neurol Sci. 2006; 248: 151-157
        • Ravina B.
        • Camicioli R.
        • Como P.G.
        • Marsh L.
        • Jankovic J.
        • Weintraub D.
        • et al.
        The impact of depressive symptoms in early Parkinson disease.
        Neurology. 2007; 69: 342-347
        • Global Parkinson's Disease Steering Committee
        Factors impacting on quality of life in Parkinson's disease: results from an international survey.
        Mov Disord. 2002; 17: 60-67
        • Lieberman A.
        Depression in Parkinson's disease-a review.
        Acta Neurol Scand. 2006; 113: 1-8
        • Nanhoe-Mahabier W.
        • de Laat K.F.
        • Visser J.E.
        • Zijlmans J.
        • de Leeuw F.E.
        • Bloem B.R.
        Parkinson disease and comorbid cerebrovascular disease.
        Nat Rev Neurol. 2009; 10: 533-541
        • Bohnen N.I.
        • Albin R.L.
        White matter lesions in Parkinson disease.
        Nat Rev Neurol. 2011; 7: 229-236
        • Beyer M.K.
        • Aarsland D.
        • Greve O.J.
        • Larsen J.P.
        Visual rating of white matter hyperintensities in Parkinson's disease.
        Mov Disord. 2006; 21: 223-229
        • Scheltens P.
        • Barkhof F.
        • Leys D.
        • Pruvo J.P.
        • Nauta J.J.
        • Vermersch P.
        • et al.
        A semiquantative rating scale forthe assessment of signal hyperintensities on mag etic resonance imaging.
        J Neurol Sci. 1993; 114: 7-12
        • Folstein M.F.
        • Folstein S.E.
        • McHugh P.R.
        “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician.
        J Psychiatr Res. 1975; 12: 189-198
        • Dalaker T.O.
        • Larsen J.P.
        • Dwyer M.G.
        • Aarsland D.
        • Beyer M.K.
        • Alves G.
        • et al.
        White matter hyperintensities do not impact cognitive function in patients with newly diagnosed Parkinson's disease.
        Neuroimage. 2009; 47: 2083-2089
        • Murray M.E.
        • Senjem M.L.
        • Petersen R.C.
        • Hollman J.H.
        • Preboske G.M.
        • Weigand S.D.
        • et al.
        Functional impact of white matter hyperintensities in cognitively normal elderly subjects.
        Arch Neurol. 2010; 67: 1379-1385
        • Pantoni L.
        • Garcia J.H.
        Pathogenesis of leukoaraiosis: a review.
        Stroke. 1997; 28: 652-659
        • Baloh R.W.
        • Yue Q.
        • Socotch T.M.
        • Jacobson K.M.
        White matter lesions and disequilibrium in older people. I. Case–control comparison.
        Arch Neurol. 1995; 52: 970-974
        • Baezner H.
        • Blahak C.
        • Poggesi A.
        • Pantoni L.
        • Inzitari D.
        • Chabriat H.
        • et al.
        Association of gait and balance disorders with age-related white matter changes: the LADIS study.
        Neurology. 2008; 70: 935-942
        • Tullberg M.
        • Fletcher E.
        • DeCarli C.
        • Mungas D.
        • Reed B.R.
        • Harvey D.J.
        • et al.
        White matter lesions impair frontal lobe function regardless of their location.
        Neurology. 2004; 63: 246-253
        • de Groot J.C.
        • de Leeuw F.E.
        • Oudkerk M.
        • Hofman A.
        • Jolles J.
        • Breteler M.M.
        Cerebral white matter lesions and depressive symptoms in elderly adults.
        Arch Gen Psychiatry. 2000; 57: 1071-1076
        • Selvarajah J.
        • Scott M.
        • Stivaros S.
        • Hulme S.
        • Georgiou R.
        • Rothwell N.
        • et al.
        Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke.
        Eur Radiol. 2009; 19: 1011-1018
        • Godin O.
        • Dufouil C.
        • Maillard P.
        • Delcroix N.
        • Mazoyer B.
        • Crivello F.
        • et al.
        White matter lesions as a predictor of depression in the elderly: the 3C-Dijon study.
        Biol Psychiatry. 2008; 63: 663-669
        • Hoptman M.J.
        • Gunning-Dixon F.M.
        • Murphy C.F.
        • Ardekani B.A.
        • Hrabe J.
        • Lim K.O.
        • et al.
        Blood pressure and white matter integrity in geriatric depression.
        J Affect Disord. 2009; 115: 171-176
        • Alexopoulos G.S.
        • Meyers B.S.
        • Young R.C.
        • Campbell S.
        • Silbersweig D.
        • Charlson M.
        'Vascular depression' hypothesis.
        Arch Gen Psychiatry. 1997; 54: 915-922
        • Hughes A.J.
        • Daniel S.E.
        • Kilford L.
        • Lees A.J.
        Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
        J Neurol Neurosurg Psychiatry. 1992; 55: 181-184
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders: DSM-IV.
        American Psychiatric Association, Washington, DC1994
        • Hamilton M.
        A rating scale for depression.
        J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
        • Fahn S.
        • Elton R.L.
        • members of the UPDRS Development Committee
        Unified Parkinson's Disease Rating Scale.
        in: Fahn S. Goldstein M. Calne D.B. Recent Developments in Parkinson's disease II. MacMillan, New York1987: 153-163
        • Hoehn M.M.
        • Yahr M.D.
        Parkinsonism: onset, progression and mortality.
        Neurology. 1967; 17: 427-442
        • Starkstein S.E.
        • Mayberg H.S.
        • Preziozi T.
        • Andrezejewski P.
        • Leiguarda R.
        • Robinson R.G.
        Reliability, validity, and clinical correlates of apathy in Parkinson's disease.
        J Neuropsychiatry Clin Neurosci. 1992; 4: 134-139
        • O'Brien J.
        • Perry R.
        • Barber R.
        • Gholkar A.
        • Thomas A.
        The association between white matter lesions on magnetic resonance imaging and noncognitive symptoms.
        Ann N Y Acad Sci. 2000; 903: 482-489
        • Greenwald B.S.
        • Kramer-Ginsberg E.
        • Krishnan K.R.R.
        • Ashtari M.
        • Auerbach C.
        • Patel M.
        Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression.
        Stroke. 1998; 29: 613-617
        • Steffens D.C.
        • Helms M.J.
        • Krishnan K.R.R.
        • Burke G.L.
        Cerebrovascular disease and depression symptoms in the cardiovascular health study.
        Stroke. 1999; 30: 2159-2166
        • O'Doherty J.
        • Kringelbach M.L.
        • Rolls E.T.
        • Hornak J.
        • Andrews C.
        Abstract reward and punishment representations in the human orbitofrontal cortex.
        Nat Neurosci. 2001; 4: 95-102
        • Cardoso E.F.
        • Maia F.M.
        • Fregni F.
        • Myczkowski L.M.
        • Melo L.M.
        • Sato J.R.
        • et al.
        Depression in Parkinson's disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus.
        Neuroimage. 2009; 47: 467-472
        • Matsui H.
        • Nishinaka K.
        • Oda M.
        • Niikawa H.
        • Komatsu K.
        • Kubori T.
        • et al.
        Depression in Parkinson's disease Diffusion tensor imaging study.
        J Neurol. 2007; 254: 1170-1173
        • Alexopoulos G.S.
        • Kiosses D.N.
        • Choi S.J.
        • Murphy C.F.
        • Lim K.O.
        Frontal white matter microstructure and treatment response of late-life depression: a preliminary study.
        Am J Psychiatry. 2002; 159: 1929-1932
        • Kostić V.S.
        • Agosta F.
        • Petrović I.
        • Galantucci S.
        • Špica V.
        • Ječmenica-Lukić M.
        • et al.
        Regional pattern of brain tisuue loss associated with depression in Parkinson disease.
        Neurology. 2010; 75: 857-863
        • Mayberg H.S.
        Frontal lobe dysfunction in secondary depression.
        in: Salloway S. Malloy P. Duffy J. The frontal lobes and neuropsychiatric illness. American Psychiatric Publishing, Washington, DC2001: 167-186
        • Starkstein S.E.
        • Berthier M.L.
        • Bolduc P.L.
        • Preziosi T.J.
        • Robinson R.G.
        Depression in patients with early versus late onset of Parkinson's disease.
        Neurology. 1989; 39: 1441-1445
        • Firbank M.J.
        • O'Brien J.T.
        • Pakrasi S.
        • Pantoni L.
        • Simoni M.
        • Erkinjuntti T.
        • et al.
        White matter hyperintensities and depression–preliminary results from the LADIS study.
        Int J Geriatr Psychiatry. 2005; 20: 674-679
        • Greenwald B.S.
        • Kramer-Ginsberg E.
        • Krishnan R.R.
        • Ashtari M.
        • Aupperle P.M.
        • Patel M.
        MRI signal hyperintensities in geriatric depression.
        Am J Psychiatry. 1996; 153: 1212-1215
        • Taylor W.D.
        • MacFall J.R.
        • Payne M.E.
        • McQuoid D.R.
        • Steffens D.C.
        • Provenzale J.M.
        • et al.
        Gretaer MRI lesion volumes in elderly depressed subjects than in control subjects.
        Psychiatry Res. 2005; 139: 1-7
        • Sheline Y.I.
        • Price J.L.
        • Vaishnavi S.N.
        • Mintun M.A.
        • Barch D.M.
        • Epstein A.A.
        • et al.
        Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors.
        Am J Psychiatry. 2008; 165: 524-532
        • Shimony J.S.
        • Sheline Y.I.
        • D'Angelo G.
        • Shimony J.S.
        • Sheline Y.I.
        • D'Angelo G.
        • et al.
        Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study.
        Biol Psychiatry. 2009; 66: 245-252
        • Herrmann L.L.
        • Le Masurier M.
        • Ebmeier K.P.
        White matter hyperintensities in late life depression: a systematic review.
        J Neurol Neurosurg Psychiatry. 2008; 79: 619-624
        • Alexopoulos G.S.
        The vascular depression hypothesis: 10 years later.
        Biol Psychiatry. 2006; 60: 1304-1305
        • Lee S.J.
        • Kim J.S.
        • Yoo J.Y.
        • Song I.U.
        • Kim B.S.
        • Jung S.L.
        • et al.
        Influence of white matter hyperintensities on the cognition of patients with Parkinson disease.
        Alzheimer Dis Assoc Disord. 2010; 24: 227-233