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Changes in regional brain volume three months after stroke

Published:August 03, 2012DOI:https://doi.org/10.1016/j.jns.2012.07.019

      Abstract

      Introduction

      Little is known about changes in regional brain volume after stroke. We investigated cortical thickness changes over 3 months in a group of stroke patients compared with controls.

      Material and methods

      Patients with acute hemispheric stroke were studied within 3 h of stroke onset and serially over 3 months. We compared the acute and 3 month scans with independently acquired control images. High resolution isotropic T1 images were analyzed using FreeSurfer V5.0, comparing regional average cortical thickness, hippocampal and thalamic volumes. Stroke patient results were analyzed separately for ipsilesional and contralesional regions, whereas control results were averaged across hemisphere. Percentage change scores between the two time points were computed for each participant, and paired sample t-tests were used to assess significant change.

      Results

      12 stroke patients (9 men, 7 left-hemispheric, mean age=65.1 years) and 10 control participants (5 men, mean age=67.2 years) were included. There were no significant differences between the 2 time points in global or regional average cortical thickness, or hippocampal and thalamic volume estimates for control subjects. Regional variability in patient data was demonstrated, particularly cortical thickness increases in contralesional paracentral, superior frontal and insular regions, areas known to be activated in functional MRI studies of motor recovery. A significant reduction in thalamic volume was also found, most apparent ipsilesionally.

      Conclusions

      Post-stroke changes in regional cortical thickness are demonstrable even over short time-frames. Contralesional cortical thickness increases may represent compensatory mechanisms. Significant reductions in thalamic volume may represent evidence of early post-stroke atrophy. Further studies are required to confirm and extend these preliminary results.

      Keywords

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      References

        • Rehme A.K.
        • Fink G.R.
        • von Cramon D.Y.
        • Grefkes C.
        The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudinal FMRI.
        Cereb Cortex. Apr 2011; 21: 756-768
        • Calautti C.
        • Jones P.S.
        • Naccarato M.
        • Sharma N.
        • Day D.J.
        • Bullmore E.T.
        • et al.
        The relationship between motor deficit and primary motor cortex hemispheric activation balance after stroke: longitudinal fMRI study.
        J Neurol Neurosurg Psychiatry. Jul 2010; 81: 788-792
        • Calautti C.
        • Leroy F.
        • Guincestre J.Y.
        • Baron J.C.
        Displacement of primary sensorimotor cortex activation after subcortical stroke: a longitudinal PET study with clinical correlation.
        Neuroimage. Aug 2003; 19: 1650-1654
        • Brodtmann A.
        • Puce A.
        • Darby D.
        • Donnan G.
        Serial functional imaging poststroke reveals visual cortex reorganization.
        Neurorehabil Neural Repair. Feb 2009; 23: 150-159
        • Fridriksson J.
        • Richardson J.D.
        • Fillmore P.
        • Cai B.
        Left hemisphere plasticity and aphasia recovery.
        Neuroimage. Apr 2 2012; 60: 854-863
        • Corbetta M.
        • Shulman G.L.
        Spatial neglect and attention networks.
        Annu Rev Neurosci. 2011; 34: 569-599
        • Calautti C.
        • Baron J.C.
        Functional neuroimaging studies of motor recovery after stroke in adults: a review.
        Stroke. Jun 2003; 34: 1553-1566
        • Marshall R.S.
        • Zarahn E.
        • Alon L.
        • Minzer B.
        • Lazar R.M.
        • Krakauer J.W.
        Early imaging correlates of subsequent motor recovery after stroke.
        Ann Neurol. May 2009; 65: 596-602
        • Askim T.
        • Indredavik B.
        • Vangberg T.
        • Haberg A.
        Motor network changes associated with successful motor skill relearning after acute ischemic stroke: a longitudinal functional magnetic resonance imaging study.
        Neurorehabil Neural Repair. Mar–Apr 2009; 23: 295-304
        • Calautti C.
        • Naccarato M.
        • Jones P.S.
        • Sharma N.
        • Day D.D.
        • Carpenter A.T.
        • et al.
        The relationship between motor deficit and hemisphere activation balance after stroke: a 3 T fMRI study.
        Neuroimage. Jan 1 2007; 34: 322-331
        • Ward N.S.
        • Newton J.M.
        • Swayne O.B.
        • Lee L.
        • Thompson A.J.
        • Greenwood R.J.
        • et al.
        Motor system activation after subcortical stroke depends on corticospinal system integrity.
        Brain. Mar 2006; 129: 809-819
        • Rehme A.K.
        • Eickhoff S.B.
        • Rottschy C.
        • Fink G.R.
        • Grefkes C.
        Activation likelihood estimation meta-analysis of motor-related neural activity after stroke.
        Neuroimage. Feb 1 2011; 59: 2771-2782
        • Wang L.E.
        • Tittgemeyer M.
        • Imperati D.
        • Diekhoff S.
        • Ameli M.
        • Fink G.R.
        • et al.
        Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study.
        Hum Brain Mapp. Oct 22 2011; ([Electronic publication ahead of print])
        • Grefkes C.
        • Fink G.R.
        Reorganization of cerebral networks after stroke: new insights from neuroimaging with connectivity approaches.
        Brain. May 2011; 134: 1264-1276
        • Rehme A.K.
        • Eickhoff S.B.
        • Wang L.E.
        • Fink G.R.
        • Grefkes C.
        Dynamic causal modeling of cortical activity from the acute to the chronic stage after stroke.
        Neuroimage. Apr 1 2011; 55: 1147-1158
        • Park C.H.
        • Chang W.H.
        • Ohn S.H.
        • Kim S.T.
        • Bang O.Y.
        • Pascual-Leone A.
        • et al.
        Longitudinal changes of resting-state functional connectivity during motor recovery after stroke.
        Stroke. May 2011; 42: 1357-1362
        • Maguire E.A.
        • Woollett K.
        • Spiers H.J.
        London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis.
        Hippocampus. 2006; 16: 1091-1101
        • Maguire E.A.
        • Gadian D.G.
        • Johnsrude I.S.
        • Good C.D.
        • Ashburner J.
        • Frackowiak R.S.
        • et al.
        Navigation-related structural change in the hippocampi of taxi drivers.
        Proc Natl Acad Sci U S A. Apr 11 2000; 97: 4398-4403
        • Foster N.E.
        • Zatorre R.J.
        Cortical structure predicts success in performing musical transformation judgments.
        Neuroimage. Oct 15 2010; 53: 26-36
        • Stein M.
        • Federspiel A.
        • Koenig T.
        • Wirth M.
        • Strik W.
        • Wiest R.
        • et al.
        Structural plasticity in the language system related to increased second language proficiency.
        Cortex. Apr 2012; 48: 458-465
        • Kraemer M.
        • Schormann T.
        • Hagemann G.
        • Qi B.
        • Witte O.W.
        • Seitz R.J.
        Delayed shrinkage of the brain after ischemic stroke: preliminary observations with voxel-guided morphometry.
        J Neuroimaging. Jul 2004; 14: 265-272
        • Nitkunan A.
        • Lanfranconi S.
        • Charlton R.A.
        • Barrick T.R.
        • Markus H.S.
        Brain atrophy and cerebral small vessel disease: a prospective follow-up study.
        Stroke. Jan 2011; 42: 133-138
        • Du A.T.
        • Schuff N.
        • Kramer J.H.
        • Rosen H.J.
        • Gorno-Tempini M.L.
        • Rankin K.
        • et al.
        Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.
        Brain. Apr 2007; 130: 1159-1166
        • Julkunen V.
        • Niskanen E.
        • Koikkalainen J.
        • Herukka S.K.
        • Pihlajamäki M.
        • Hallikainen M.
        • et al.
        Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients a longitudinal study.
        J Alzheimers Dis. 2010; 21: 1141-1151
        • Salat D.H.
        • Buckner R.L.
        • Snyder A.Z.
        • Greve D.N.
        • Desikan R.S.
        • Busa E.
        • et al.
        Thinning of the cerebral cortex in aging.
        Cereb Cortex. Jul 2004; 14: 721-730
        • Karl J.M.
        • Alaverdashvili M.
        • Cross A.R.
        • Whishaw I.Q.
        Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis.
        Neuroscience. Sep 29 2010; 170: 123-137
        • Pohjasvaara T.
        • Mantyla R.
        • Salonen O.
        • Aronen H.J.
        • Ylikoski R.
        • Hietanen M.
        • et al.
        How complex interactions of ischemic brain infarcts, white matter lesions, and atrophy relate to poststroke dementia.
        Arch Neurol. Sep 2000; 57: 1295-1300
        • Stebbins G.T.
        • Nyenhuis D.L.
        • Wang C.
        • Cox J.L.
        • Freels S.
        • Bangen K.
        • et al.
        Gray matter atrophy in patients with ischemic stroke with cognitive impairment.
        Stroke. Mar 2008; 39: 785-793
        • Pendlebury S.T.
        • Rothwell P.M.
        Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis.
        Lancet Neurol. Nov 2009; 8: 1006-1018
        • Ferri C.P.
        • Prince M.
        • Brayne C.
        • Brodaty H.
        • Fratiglioni L.
        • Ganguli M.
        • et al.
        Global prevalence of dementia: a Delphi consensus study.
        Lancet. Dec 17 2005; 366: 2112-2117
        • Jack Jr., C.R.
        • Lowe V.J.
        • Weigand S.D.
        • Wiste H.J.
        • Senjem M.L.
        • Knopman D.S.
        • et al.
        Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.
        Brain. May 2009; 132: 1355-1365
        • Jack Jr., C.R.
        • Shiung M.M.
        • Weigand S.D.
        • O'Brien P.C.
        • Gunter J.L.
        • Boeve B.F.
        • et al.
        Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI.
        Neurology. Oct 25 2005; 65: 1227-1231
        • Seshadri S.
        • Wolf P.A.
        • Beiser A.
        • Elias M.F.
        • Au R.
        • Kase C.S.
        • et al.
        Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study.
        Neurology. Nov 9 2004; 63: 1591-1599
        • Elias M.F.
        • Beiser A.
        • Wolf P.A.
        • Au R.
        • White R.F.
        • D'Agostino R.B.
        The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort.
        Arch Neurol. Jun 2000; 57: 808-813
        • Fischl B.
        • Sereno M.I.
        • Dale A.M.
        Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system.
        Neuroimage. Feb 1999; 9: 195-207
        • Dale A.M.
        • Fischl B.
        • Sereno M.I.
        Cortical surface-based analysis. I. Segmentation and surface reconstruction.
        Neuroimage. Feb 1999; 9: 179-194
        • Fjell A.M.
        • Westlye L.T.
        • Amlien I.
        • Espeseth T.
        • Reinvang I.
        • Raz N.
        • et al.
        High consistency of regional cortical thinning in aging across multiple samples.
        Cereb Cortex. Sep 2009; 19: 2001-2012
        • Pantelis C.
        • Velakoulis D.
        • McGorry P.D.
        • Wood S.J.
        • Suckling J.
        • Phillips L.J.
        • et al.
        Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.
        Lancet. Jan 25 2003; 361: 281-288
        • Weiner M.W.
        • Aisen P.S.
        • Jack Jr., C.R.
        • Jagust W.J.
        • Trojanowski J.Q.
        • Shaw L.
        • et al.
        The Alzheimer's disease neuroimaging initiative: progress report and future plans.
        Alzheimers Dement. May 2010; 6 ([e7]): 202-211
        • Pohjasvaara T.
        • Mantyla R.
        • Salonen O.
        • Aronen H.J.
        • Ylikoski R.
        • Hietanen M.
        • et al.
        MRI correlates of dementia after first clinical ischemic stroke.
        J Neurol Sci. Dec 1 2000; 181: 111-117
        • Sachdev P.S.
        • Chen X.
        • Joscelyne A.
        • Wen W.
        • Altendorf A.
        • Brodaty H.
        Hippocampal size and dementia in stroke patients: the Sydney stroke study.
        J Neurol Sci. Sep 15 2007; 260: 71-77
        • Konrad C.
        • Ukas T.
        • Nebel C.
        • Arolt V.
        • Toga A.W.
        • Narr K.L.
        Defining the human hippocampus in cerebral magnetic resonance images—an overview of current segmentation protocols.
        Neuroimage. Oct 1 2009; 47: 1185-1195
        • Tae W.S.
        • Kim S.S.
        • Lee K.U.
        • Nam E.C.
        • Kim K.W.
        Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder.
        Neuroradiology. Jul 2008; 50: 569-581
        • Jovicich J.
        • Czanner S.
        • Han X.
        • Salat D.
        • van der Kouwe A.
        • Quinn B.
        • et al.
        MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths.
        Neuroimage. May 15 2009; 46: 177-192
        • Good C.D.
        • Johnsrude I.S.
        • Ashburner J.
        • Henson R.N.
        • Friston K.J.
        • Frackowiak R.S.
        A voxel-based morphometric study of ageing in 465 normal adult human brains.
        Neuroimage. Jul 2001; 14: 21-36
        • Scheltens P.
        • Leys D.
        • Barkhof F.
        • Huglo D.
        • Weinstein H.C.
        • Vermersch P.
        • et al.
        Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.
        J Neurol Neurosurg Psychiatry. Oct 1992; 55: 967-972
        • Dewey J.
        • Hana G.
        • Russell T.
        • Price J.
        • McCaffrey D.
        • Harezlak J.
        • et al.
        Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study.
        Neuroimage. Jul 15 2010; 51: 1334-1344
        • Rohrer J.D.
        • Warren J.D.
        • Modat M.
        • Ridgway G.R.
        • Douiri A.
        • Rossor M.N.
        • et al.
        Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration.
        Neurology. May 5 2009; 72: 1562-1569
        • Klauschen F.
        • Goldman A.
        • Barra V.
        • Meyer-Lindenberg A.
        • Lundervold A.
        Evaluation of automated brain MR image segmentation and volumetry methods.
        Hum Brain Mapp. Apr 2009; 30: 1310-1327
        • Murphy T.H.
        • Corbett D.
        Plasticity during stroke recovery: from synapse to behaviour.
        Nat Rev Neurosci. Dec 2009; 10: 861-872
        • Seidler R.D.
        • Noll D.C.
        Neuroanatomical correlates of motor acquisition and motor transfer.
        J Neurophysiol. Apr 2008; 99: 1836-1845
        • Ward N.S.
        Mechanisms underlying recovery of motor function after stroke.
        Postgrad Med J. Aug 2005; 81: 510-514
        • Van Paesschen W.
        Qualitative and quantitative imaging of the hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis.
        Neuroimaging Clin N Am. Aug 2004; 14 ([vii]): 373-400