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Cognitive assessment protocol design in the ISSYS (Investigating Silent Strokes in hYpertensives: A magnetic resonance imaging Study)

  • I. Riba
    Affiliations
    Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • C.I. Jarca
    Affiliations
    Primary Care, CUAP Horta, SAP Muntanya, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • X. Mundet
    Affiliations
    Unitat de Suport a la Recerca Barcelona Ciutat‐IDIAP Jordi Gol i Gurina, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • J.L. Tovar
    Affiliations
    Nephrology Service, Vall Hebron's General University Hospital, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • F. Orfila
    Affiliations
    Unitat de Suport a la Recerca, Barcelona Ciutat, Institut Universitari d'Investigació en Atenció Primària (IDIAP) Jordi Gol, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • C. Nafría
    Affiliations
    Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • A. Raga
    Affiliations
    Primary Care, CAP Encants, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • A. Girona
    Affiliations
    Primary Care, CAP San Roc, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • P. Fernández-Lara
    Affiliations
    Neurorradiology, Clínica Dr. Manchón, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • X. Castañé
    Affiliations
    Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • J. Álvarez Sabin
    Affiliations
    Neurology Service, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • I. Fernández Cortiñas
    Affiliations
    Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • O. Maisterra
    Affiliations
    Neurology Service, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • J. Montaner
    Affiliations
    Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain

    Neurology Service, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
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  • P. Delgado
    Correspondence
    Corresponding author at: Neurovascular Research Lab, Institut de Recerca Vall d'Hebron, Passeig Vall d'Hebron 119‐129, CP 08035 Barcelona, Spain. Tel.: +34 934894029; fax: +34 934894015.
    Affiliations
    Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
    Search for articles by this author

      Abstract

      Hypertension and silent cerebrovascular lesions (SCL) detected by brain magnetic resonance imaging (MRI) are associated with an increased risk of cognitive decline. In a prospective observational study in 1000 hypertensive patients, aged 50–70 years, with no prior history of stroke or dementia, we will study the presence of mild cognitive impairment (MCI) and the relationship between SCL and cognition. All participants will be assessed by means of the Dementia Rating Scale—2 (DRS-2) and will undergo a brain MRI. In order to better characterize MCI and future dementia risk in our cohort, those patients that are suspected to be cognitively impaired according to the DRS-2 results will have a further neurological evaluation and complete neuropsychological testing. Follow-up for the entire cohort is planned to last for at least 3 years.

      Keywords

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