Abstract
Hypertension and silent cerebrovascular lesions (SCL) detected by brain magnetic resonance
imaging (MRI) are associated with an increased risk of cognitive decline. In a prospective
observational study in 1000 hypertensive patients, aged 50–70 years, with no prior history of stroke or dementia, we will study the presence of
mild cognitive impairment (MCI) and the relationship between SCL and cognition. All
participants will be assessed by means of the Dementia Rating Scale—2 (DRS-2) and
will undergo a brain MRI. In order to better characterize MCI and future dementia
risk in our cohort, those patients that are suspected to be cognitively impaired according
to the DRS-2 results will have a further neurological evaluation and complete neuropsychological
testing. Follow-up for the entire cohort is planned to last for at least 3 years.
Keywords
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References
- Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease.Neurology. 2011; 76: 1485-1491
- Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.Arch Neurol. 2003; 60: 1385-1389
- Rate of progression of mild cognitive impairment to dementia—meta-analysis of 41 robust inception cohort studies.Acta Psychiatr Scand. 2009; 119: 252-265
- Patterns of cognitive decline and rates of conversion to dementia in patients with degenerative and vascular forms of MCI.Curr Alzheimer Res. 2011; 8: 24-31
- Mild cognitive impairment subtypes and vascular dementia in community-dwelling elderly people: a 3-year follow-up study.J Am Geriatr Soc. 2006; 54: 580-586
- Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature.World J Biol Psychiatry. 2008; 9: 172-182
- Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design.J Alzheimers Dis. 2010; 20: 881-891
- Predictive value of APOE-epsilon4 allele for progression from MCI to AD-type dementia: a meta-analysis.J Neurol Neurosurg Psychiatry. 2011; 82: 1149-1156
- Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment.Neurology. 1999; 52: 1397-1403
- Comparing predictors of conversion and decline in mild cognitive impairment.Neurology. 2010; 75: 230-238
- Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia: a prospective cohort study.BMJ Open. 2011 Jan 1; 1: e000007
- White matter disease independently predicts progression from mild cognitive impairment to Alzheimer's disease in a clinic cohort.Dement Geriatr Cogn Disord. 2011; 31: 431-434
- Hypertension and dementia.Am J Hypertens. 2010; 23: 116-124
- Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study.Neurology. 2001; 56: 1683-1689
- Ambulatory blood pressure as an independent determinant of brain atrophy and cognitive function in elderly hypertension.J Hypertens. 2008; 26: 1636-1641
- Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients.Stroke. 2008; 39: 2046-2051
- Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study.Stroke. 2008; 39: 2712-2719
- Silent brain infarcts: a systematic review.Lancet Neurol. 2007; 6: 611-619
- MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson–Lewy body dementias.J Neurol Sci. 2007; 257: 97-104
- Cerebral infarcts and cognitive performance: importance of location and number of infarcts.Stroke. 2009; 40: 677-682
- Dementia Rating Scale—2. Professional manual.Psychological Assessment Resources, Inc., 2001
- The money test.Neurology. 2002; 58: A274
- Cut-off score of the Mattis Dementia Rating Scale for screening dementia in Parkinson's disease.Mov Disord. 2008; 23: 1546-1550
- Estudio normativo de la Dementia Rating Scale-2 en una muestra poblacional española mayor de 60 años.Universidad de Salamanca, Salamanca2010
- Spanish Multicenter Normative Studies (NEURONORMA Project): methods and sample characteristics.Arch Clin Neuropsychol. 2009; 24: 307-319
- Clinical validity and utility of the interview for deterioration of daily living in dementia for Spanish-speaking communities NORMACODEM Group.Int Psychogeriatr. 1998; 10: 261-270
- Statistical evaluation and Castillian adaptation of the self applied scale for Zung Depression.Arch Neurobiol (Madr). 1970; 33: 185-206
Olazarán Rodríguez J, Molinuevo Guix JL, Peña Casanova J. Deterioro cognitivo ligero. En: Grupo de estudio de Neurología de la Conducta y Demencias, Sociedad Española de Neurología, editores. Guía Oficial para la práctica clínica en demencias: conceptos, criterios y recomendaciones. Barcelona: Prous Science; 2009. p. 15–21.
- Current concepts in mild cognitive impairment.Arch Neurol. 2001; 58: 1985-1992
- Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease.Stroke. 2010; 41: 450-454
- Silent brain infarcts: a review of MRI diagnostic criteria.Stroke. 2011; 42: 1140-1145
- Improving interrater agreement about brain microbleeds: development of the Brain Observer MicroBleed Scale (BOMBS).Stroke. 2009; 40: 94-99
- A new rating scale for age-related white matter changes applicable to MRI and CT.Stroke. 2001; 32: 1318-1322
- Adaptation and convergent validity of a telephone-based Mini-Mental State Examination.Med Clin (Barc). 2008; 131: 89-95
- Neuropsychological assessment.4th ed. Oxford University Press, New York2004
- WAIS-III/WMS-III technical manual.The Psychological Corporation, San Antonio1997
- Spanish Multicenter Normative Studies (NEURONORMA Project): norms for verbal span, visuospatial span, letter and number sequencing, trail making test, and symbol digit modalities test.Arch Clin Neuropsychol. 2009; 24: 321-341
- Spanish Multicenter Normative Studies (NEURONORMA Project): norms for verbal fluency tests.Arch Clin Neuropsychol. 2009; 24: 395-411
- Spanish Multicenter Normative Studies (NEURONORMA Project): norms for the Stroop color–word interference test and the Tower of London-Drexel.Arch Clin Neuropsychol. 2009; 24: 413-429
- Test Barcelona.Masson SA, Barcelona1990
Article info
Publication history
Published online: July 26, 2012
Footnotes
☆Conflict of interest: none.
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© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
