Advertisement

Psychopharmacologic intervention after hemorrhagic basal ganglia damage

      Abstract

      Traumatic brain injury (TBI) can result in cognitive and behavioral impairments such as poor attention, learning, memory and planning ability and uncontrolled crying that can be more persistent problems than the physical disabilities. Cognitive enhancers have been shown to improve cognitive and behavioral impairments in patients with hemorrhagic basal ganglia lesions as well as other forms of TBI. There is little research about the use of cognitive enhancers after hemorrhagic basal ganglia damage. We present a case of a 38 year old male who made significant recovery with the use of cognitive enhancers.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Mohamed A.D.
        • Sahakian B.J.
        The ethics of elective psychopharmacology.
        Int J Neuropsychopharmacol. 2011; 14: 1-13
        • Polo M.D.
        • Newton P.
        • Rogers D.
        • Escera C.
        • Butler S.
        ERPs and behavioural indices of long-term preattentive and attentive deficits after closed head injury.
        Neuropsychologia. 2002; 40: 2350-2359
        • Salmond C.H.
        • Sahakian B.J.
        Cognitive outcome in traumatic brain injury survivors.
        Curr Opin Crit Care. 2005; 11: 111-116
        • Salmond C.H.
        • Chatfield D.A.
        • Menon D.K.
        • Pickard J.D.
        Cognitive sequelae of head injury: involvement of basal forebrain and associated structures.
        Brain. 2005; 128: 189-200
        • Tenovuo O.
        Central acetylcholinesterase inhibitors in the treatment of chronic traumatic brain injury: clinical experience in 111 patients.
        Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29: 61-67
        • DeVito E.E.
        • Blackwell A.D.
        • Kent L.
        • Ersche K.D.
        • Clark L.
        • Salmond C.H.
        • et al.
        The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2008; 64: 636-639
        • Turner D.C.
        • Dowson J.
        • Robbins T.W.
        • Sahakian B.J.
        Modafinil improves cognition and response inhibition in adult ADHD.
        Biol Psychiatry. 2004; 55: 1031-1040
        • Andersen G.
        • Stylsvig M.
        • Sunde N.
        Citalopram treatment of traumatic brain damage in a 6-year-old boy.
        J Neurotrauma. 1999; 4: 341-344
        • Andersen G.
        • Vestergaard K.
        • Riis J.O.
        Citalopram for post-stroke pathological crying.
        Lancet. 1993; 342: 837-839
        • Benke T.
        • Delazer M.
        • Bartha L.
        • Basal Auer A.
        Ganglia lesions and the theory of fronto-subcortical loops: neuropsychological findings in two patients with left caudate lesions.
        Neurocase. 2003; 1: 70-85
        • Vanderploeg R.D.
        • Schwab K.
        • Walker W.C.
        • Fraser J.A.
        • Sigford B.J.
        • Date E.S.
        • et al.
        Rehabilitation of traumatic brain injury in active duty military personnel and veterans: defense and veterans brain injury center randomized controlled trial of two rehabilitation approaches.
        Arch Phys Med Rehabil. 2008; 12: 2227-2238
        • Morey C.E.
        • Cilo M.
        • Berry J.
        The effect of Aricept in persons with persistent memory disorder following traumatic brain injury: a pilot study.
        Brain Inj. 2003; 17: 809-815
        • Zhang L.
        • Plotkin R.C.
        • Wang G.
        Cholinergic augmentation with donepezil enhances recovery in short term memory and sustained attention after traumatic brain injury.
        Arch Phys Med Rehabil. 2004; 85: 1050-1055
        • Lee H.
        • Kim S.W.
        • Kim J.M.
        Comparing effects of methylphenidate, sertraline, and placebo on neuropsychiatric sequelae in patients with traumatic brain injury.
        Hum Psychopharmacol Clin Exp. 2005; 20: 97-104
        • Gualtieri C.T.
        • Evans R.W.
        Stimulant treatment for the neurobehavioral sequelae of traumatic brain injury.
        Brain Inj. 1988; 2: 273-290
        • Plenger P.M.
        • Dixon C.E.
        • Castillo R.M.
        • Frankowski R.F.
        • Yablon S.A.
        • Levin H.S.
        Subacute methylphenidate treatment for moderate to moderately severe traumatic brain injury: a preliminary double-blind placebo-controlled study.
        Arch Phys Med Rehabil. 1996; 77: 536-540
        • Whyte J.
        • Hart T.
        • Schuster K.
        • Fleming M.
        • Polansky M.
        • Coslett H.B.
        Effects of methylphenidate on attentional function after traumatic brain injury: a randomized, placebo-controlled trial.
        Am J Phys Med Rehabil. 1997; 76: 440-450
        • Mahalick D.M.
        • Carmel P.W.
        • Greenberg J.P.
        • Molofsky W.
        • Brown J.A.
        • Heary R.F.
        • et al.
        Psychopharmacologic treatment of acquired attention disorders in children with brain injury.
        Pediatr Neurosurg. 1998; 29: 121-126
        • Whyte J.
        • Hart T.
        • Vaccaro M.
        • Grieb-Neff P.
        • Risser A.
        • Polansky M.
        • et al.
        Effects of methylphenidate on attention deficits after traumatic brain injury: a multidimensional, randomized, controlled trial.
        Am J Phys Med Rehabil. 2004; 83: 401-420
        • Kaelin D.L.
        • Cifu D.X.
        • Matthies B.
        Methylphenidate effect on attention deficit in the acutely brain-injured adult.
        Arch Phys Med Rehabil. 1996; 77: 6-9