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Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases

  • Stefan Spulber
    Affiliations
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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  • Nenad Bogdanovic
    Affiliations
    Division of Experimental Geriatrics, Alzheimer's Disease Research Center, Department of NVS, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
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  • Mihaela Oana Romanitan
    Affiliations
    Department of Neurology, University Hospital Bucharest, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
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  • Ovidiu A. Bajenaru
    Affiliations
    Department of Neurology, University Hospital Bucharest, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
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  • Bogdan O. Popescu
    Correspondence
    Corresponding author at: ‘Victor Babeş’ National Institute of Pathology, Laboratory of Molecular Medicine, 99‐101, Spl. Independenței, sector 5, 050096 Bucharest, Romania. Tel.: +40 744 353433.
    Affiliations
    Department of Neurology, University Hospital Bucharest, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania

    Laboratory of Molecular Medicine, ‘Victor Babeş’ National Institute of Pathology, Bucharest, Romania
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      Abstract

      We have reported earlier that tight-junction proteins are detectable by standard immunohistochemistry in the brain parenchyma, namely in the cell bodies of neurons, astrocytes, and oligodendrocytes. Here we show, by projection to latent structures — discriminate analysis (PLS-DA), that the immunohistochemical detection profile of tight junction proteins clearly distinguishes the AD cases from healthy aging controls and from the cases of dementia with a predominantly vascular pathology underlying the symptoms (vascular dementia, VaD; cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL; and cerebral amyloid angiopathy, CAA). Our findings might be valuable in the perspective of developing biomarkers for AD.

      Keywords

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