Abstract
We have reported earlier that tight-junction proteins are detectable by standard immunohistochemistry
in the brain parenchyma, namely in the cell bodies of neurons, astrocytes, and oligodendrocytes.
Here we show, by projection to latent structures — discriminate analysis (PLS-DA),
that the immunohistochemical detection profile of tight junction proteins clearly
distinguishes the AD cases from healthy aging controls and from the cases of dementia
with a predominantly vascular pathology underlying the symptoms (vascular dementia,
VaD; cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,
CADASIL; and cerebral amyloid angiopathy, CAA). Our findings might be valuable in
the perspective of developing biomarkers for AD.
Keywords
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Article info
Publication history
Published online: June 04, 2012
Identification
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© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
