Abstract
Background
The prognostic value of serum uric acid (UA) in acute ischemic stroke is controversial.
The aim of this study is to further analyse the relation between UA and outcome after
acute ischemic stroke.
Methods
We analysed UA levels in blood samples collected within 6 h of stroke onset from patients included in the placebo arm of the US and Canadian
Lubeluzole Ischemic Stroke Study (LUB-INT-9). We compared mean serum UA levels in
patients with and without early neurological improvement (≥4 versus <4 points improvement on NIHSS after 5 days) and in patients with good functional and poor functional outcome (mRS 0–2 versus
mRS 3–6). Multivariable logistic regression analyses were performed to adjust for
possible confounders.
Results
UA levels of 226 patients were available for analysis. Mean serum UA levels were not
significantly higher in patients with than without early neurological improvement
(0.33 mmol/L versus 0.30 mmol/L, p=0.070). The difference between patients with good and patients with poor functional
outcome was borderline statistically significant (0.34 mmol/L versus 0.31 mmol/L, p=0.050). After adjustment for confounders, higher serum UA levels were neither associated
with early neurological improvement OR (1.30, 95% CI 0.98–1.73, p=0.069), nor with a good functional outcome (OR 1.09, 95% CI 0.72–1.65, p=0.690).
Conclusion
We found no association between admission serum UA levels and both short- and long-term
outcome in acute ischemic stroke.
Keywords
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Article info
Publication history
Published online: May 28, 2012
Accepted:
May 4,
2012
Received in revised form:
May 1,
2012
Received:
March 15,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
