Abstract
We investigated the magnetic resonance imaging (MRI) findings of 32 multiple sclerosis
(MS) patients using voxel-based morphometry (VBM) and voxel-based analysis of white
matter fluid-attenuated inversion recovery image (FLAIR) high-intensity lesions and
diffusion tensor imaging (DTI). Compared with 18 healthy controls, MS patients showed
gray matter volume reduction in the thalamus, hypothalamus, caudate, limbic lobe,
and frontal lobe. A marked volume reduction of white matter was evident along the
ventriculus lateralis and corpus callosum. FLAIR high-intensity lesions were observed
beside the ventriculus lateralis. DTI revealed reduced fractional anisotropy areas
similar to those of the FLAIR high-intensity lesions. Changes in the volume of increased
mean diffusivity (MD) were the most widespread and extended to normal-appearing white
matter (p<0.001). Multiple regression analysis revealed that MD values were significantly correlated
with both disease duration (r=0.381, p=0.032) and expanded disability status scale scores (EDSS) (r=0.393, p=0.026). This study demonstrated that combined voxel-based analysis for volumetry,
FLAIR high-intensity lesions, and DTI could reveal widespread brain abnormalities
in MS patients. Furthermore, DTI, especially MD, showed far more widespread brain
degeneration than other MRI parameters, and was significantly correlated with both
severity and disease duration.
Keywords
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Article info
Publication history
Published online: May 25, 2012
Accepted:
April 30,
2012
Received in revised form:
April 18,
2012
Received:
October 4,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
