Abstract
Background
Some recent studies have shown that poor outcomes after acute ischemic stroke (AIS)
were closely related to lower serum triglyceride (TG) levels, not hypertriglyceridemia.
However, hypertriglyceridemia has been shown to be an independent predictor for poor
outcome in patients with coronary artery disease. This study attempted to evaluate
the association between serum TG levels and early prognosis of AIS.
Methods
We enrolled 736 consecutive patients with AIS. Based on the TG level, patients were
divided into 5 groups based on the guidelines of the National Cholesterol Education
Program (NCEP). We defined early neurological deterioration (END) as a 4-point or
greater deterioration of the NIH stroke scale (NIHSS) score and early clinical improvement
(ECI) as a 4-point reduction of NIHSS within a week after symptom onset. We compared
patients with END, ECI, and neither END nor ECI.
Results
The risk of END was significantly higher in the hyperTG and hypoTG groups compared
with the normal group. The percentages of ECI were significantly lower in the hypoTG,
borderline, and hyperTG groups compared with the normal group. For END, the multivariable
adjusted odds ratios were significantly higher in the hypoTG, borderline, and hyperTG
groups compared with the low normal group (50 to 100 mg/dl).
Conclusions
TG had a nonlinear, J-shaped association with poor outcome and a reverse J-shaped
association with good outcome in AIS. This study suggests that both hyperTG and hypoTG
can be risk factors for poor early outcome in AIS.
Keywords
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Article info
Publication history
Published online: May 14, 2012
Accepted:
April 18,
2012
Received in revised form:
April 18,
2012
Received:
January 17,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
