Abstract
Animal studies have shown that cerebral hypoperfusion may be associated with amyloid
plaque accumulation. Amyloid plaque is known to be associated with dementia and [18F]AV-45 is a positron emission tomography (PET) ligand that binds to extracelluar
plaques. We hypothesized that demented patients with cerebral hypoperfusion may have
increased [18F]AV-45 uptake.
Five demented patients with cerebral hypoperfusion due to unilateral carotid artery
stenosis (CAS) were examined with [18F]AV-45 PET, and the results were compared with six elderly controls. The standard
uptake value ratio (SUVR) of each region of interest (ROI) was created using whole
cerebellum as the reference region. All subjects underwent magnetic resonance imaging
(MRI) for obtaining structural information.
Patients with dementia and unilateral CAS had a higher global [18F]AV-45 SUVR (1.34±0.06) as compared with controls (1.10±0.04, p=0.0043), especially over the frontal, temporal, precuneus, anterior cingulate and
occipital regions. The statistical distribution maps revealed a significantly increased
[18F]AV-45 SUVR in the medial frontal, caudate, thalamus, posterior cingulate, occipital
and middle and superior temporal regions ipsilateral to the side of CAS (p<0.01).
The present study found that cerebral [18F]AV-45 binding is increased in demented patients with CAS, and its distribution is
lateralized to the CAS side, suggesting that amyloid‐related dementia may occur under
cerebral hypoperfusion.
Keywords
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Article info
Publication history
Published online: May 10, 2012
Accepted:
April 13,
2012
Received in revised form:
March 21,
2012
Received:
November 23,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
