Abstract
Familial Creutzfeldt-Jakob disease (CJD) with V180I shows different clinical characteristics
from classical CJD and is difficult to diagnose in the early stage. We report a CJD180
patient in whom results of diffusion-weighted imaging (DWI) led us to suspect CJD
before symptoms started. A 68-year-old woman presented to our hospital with headache
and nausea and underwent magnetic resonance imaging. DWI showed cortical hyperintensity.
Three months later, cognitive function started to decline and CJD180 was diagnosed
following genetic examination. In the early stage, ADC values were not decreased and
single positron emission computed tomography demonstrated a decreased pattern like
Alzheimer disease.
Keywords
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Article info
Publication history
Published online: May 29, 2012
Accepted:
April 3,
2012
Received in revised form:
April 2,
2012
Received:
December 20,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
