Abstract
The burden of cognitive disorders is likely to increase over the coming years due
to both increased longevity and altered risk factor patterns, arising from changes
in lifestyle, healthcare and society. Vascular dementia with its underlying heterogeneous
pathology, is a challenge for clinicians, and is frequently further aggravated by
overlap with other neurodegenerative processes. Current Alzheimer's disease drugs
have had limited clinical efficacy in treating vascular dementia and none have been
approved by major regulatory authorities specifically for this disease. Moving forward,
a valid choice may be a multimodal therapy, as has already been successfully proven
in Alzheimer's disease. Actovegin, a hemodialysate derived from calf blood, has been
shown to have effects on a variety of cellular processes and a recent experimental
study has revealed its neuroprotective mechanisms of action. These data, coupled with
positive results from clinical trials in mixed dementia populations, have served as
a foundation for the design of a new trial investigating the efficacy and disease-modifying
effects of Actovegin in post-stroke cognitive impairment.
Keywords
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Article info
Publication history
Published online: April 03, 2012
Accepted:
February 16,
2012
Received in revised form:
February 13,
2012
Received:
February 10,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
