In this issue of J Neurol Sci, Cappellari and colleagues [
] reported very important information that statin treatment beginning before stroke and continued during the acute phase was associated with symptomatic intracerebral hemorrhage and statin treatment beginning within 24 h after IV thrombolysis may improve short- and long-term outcome. Although the data were analyzed by statistical methods, the data should be interpreted with caution.
- Cappellari M.
- Deluca C.
- Tinazzi M.
- Tomelleri G.
- Carletti M.
- Fiaschi A.
- et al.
Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study.
J Neurol Sci. 2011; 308 (15): 128-134
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- Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study.J Neurol Sci. 2011; 308 (15): 128-134
- Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis.Stroke. 2004; 35: 2902-2909
- Lipid management in the prevention of stroke:review and updated meta-analysis of statins for stroke prevention.Lancet Neurol. 2009; 8: 453-463
- Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.Stroke. 2008; 39: 3297-3302
- Clinicoradiological Profile and Serum Lipid Levels of Intracerebral Hemorrhage in Prior Statin Users.Intern Med. 2011; 50: 1385-1391
Published online: October 20, 2011
Received: September 12, 2011
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.