Fang and Wu argue that the lack of measurement of the initial total cholesterol (TC)
levels might be a selection bias, resulting in overestimation of intracerebral hemorrhage
(ICH) in patients who started statin before stroke and continued this treatment in
the acute phase of ischemic stroke in our study [
[1]
]. They reported that prior statin use with TC levels ≤150 mg/dL was associated with hematoma volume and worsening outcome in Miura group's study
[
[2]
].To read this article in full you will need to make a payment
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References
- Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study.J Neurol Sci. 2011; 308: 128-134
- Clinicoradiological profile and serum lipid levels of intracerebral hemorrhage in prior statin users.Intern Med. 2011; 50: 1385-1391
- Cholesterol measured before stroke thrombolysis is not associated with tissue plasminogen activator-related hemorrhagic transformation.Stroke. 2008; 39: e6
- Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observation study.Lancet. 2007; 369: 275-282
- Lipid profile, statin use, and outcome after intravenous thrombolysis for acute ischemic stroke.J Neurol. 2008; 255: 875-880
- Prior statin use, intracranial hemorrhage and outcome after intra-arterial thrombolysis for acute ischemic stroke.Stroke. 2009; 40: 1729-1737
- The acute (cerebro)vascular effects of statins.Anesth Analg. 2009; 109: 572-584
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Article info
Publication history
Published online: October 17, 2011
Accepted:
September 20,
2011
Received:
September 19,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
