Research Article| Volume 311, ISSUE 1-2, P50-57, December 15, 2011

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An ecological study of industry in a high-risk region of multiple sclerosis

Published:October 10, 2011DOI:


      The county of Värmland, Sweden, has shown a high frequency of multiple sclerosis in several investigations. It has been presented in three studies; a period prevalence study in 1925–1934, a mortality study during 1952–1992 and a prevalence investigation in 2002.
      The aim of this study was to investigate the pattern of industry in this high-risk area for multiple sclerosis.
      The three investigations were correlated with industry in 1913 and in the 1950s, all analyzed by the Kruskall–Wallis test. Select industries from wood-pulp, paper and iron/mechanical sectors were tested also in whole Sweden. The Spearman rank correlation was used for these data and forestry data in Värmland.
      In Värmland, industrial data from 1913 revealed that large sawmills were associated with the period prevalence in 1925–1934 and there was a possible correlation with the prevalence for 2002. Wood-pulp factories showed a possible association with the prevalence 1925–1934 and the mortality 1952–1992. Some industries in the 1950s were correlated with the prevalence 2002.
      Wood and paper industries in Sweden 1913 showed an association with the MS mortality 1952–1992.
      In summary, data on MS prevalence in Värmland and mortality both in Värmland and all Sweden from the past 100 years suggest an association with wood-related industries in 1913 and in the 1950s, whereas no consistent association was found for other industries.


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        • Ascherio A.
        • Munger K.
        Epidemiology of multiple sclerosis: from risk factors to prevention.
        Semin Neurol. 2008; 28: 17-28
        • Lauer K.
        Environmental risk factors in multiple sclerosis.
        Exp Rev Neurother. 2010; 10: 421-440
        • Zuvich R.L.
        • McCauley J.L.
        • Pericak-Vance M.A.
        • Haines J.L.
        Genetics and pathogenesis of multiple sclerosis.
        Sem Immunol. 2009; 21: 328-333
        • Oksenberg J.R.
        • Baranzini S.E.
        Multiple sclerosis genetics — is the glass half full, or half empty?.
        Nat Rev Neurol. 2010; 6: 429-439
        • Eikelenboom M.J.
        • Killestein J.
        • Kragt J.J.
        • Uitdehaag B.M.
        • Polman C.H.
        Gender difference in multiple sclerosis: cytokines and vitamin D.
        J Neurol Sc. 2009; 286: 40-42
        • Ramagopalan S.V.
        • Dobson R.
        • Meier U.C.
        • Giovannoni G.
        Multiple sclerosis: risk factors, prodromes, and potential causal pathways.
        Lancet Neurol. 2010; 9: 727-739
        • Stocks P.
        Multiple sclerosis distributions in England and Wales and parts of Europe.
        J Hyg. 1971; 69: 373-389
        • Beltrán I.
        • Moltó-Jordà J.M.
        • Díaz-Marín C.
        • Martín R.
        • Matías-Guiu J.
        Analytical epidemiological study of multiple sclerosis in Alcoi.
        Rev Neurol. 1998; 26 (in Spanish): 67-69
        • Lauer K.
        Risk of multiple sclerosis in relation to industrial activities: an ecological study in four European countries.
        Neuroepidemiology. 1989; 8: 38-42
        • Lauer K.
        • Plaum T.
        Multiple sclerosis (MS) mortality in the state of Rhineland-Palatinate, Germany, in geographical relation to medical, geoclimatic and social variables: an ecological study.
        Eur J Neurol. 1998; 5: 126
      1. Böhme A. The mortality of multiple sclerosis in the Federal State of North Rhine-Westphalia in spatial relation to geographical and socio-economic variables with special reference to the environmental burden. Frankfurt : Thesis, 2005 (in German).

        • Lauer K.
        Environmental associations with the risk of MS: the contribution of ecological studies.
        Acta Neurol Scand. 1995; 91: 77-88
        • Lauer K.
        • Firnhaber W.
        Mortality data on multiple sclerosis: spatial distribution and correlation with socio-geographic variables.
        Verh Dtsch Ges Neurol. 1989; 5 (in German): 615-618
        • Darmstaedter E.
        The mortality of multiple sclerosis 1975–1995 in the State of Lower Saxony, northern Germany.
        Mult Scler. 2008; 14: S189
        • Landtblom A.M.
        Exposure to organic solvents and multiple sclerosis.
        Neurology. 1997 Aug; 49: S70-S74
        • Landtblom A.M.
        • Flodin U.
        • Söderfeldt B.
        • Wolfson C.
        • Axelson O.
        Organic solvents and multiple sclerosis: a synthesis of the current evidence.
        Epidemiology. 1996 Jul; 7: 429-433
        • Landtblom A.M.
        • Wastenson M.
        • Ahmadi A.
        • Söderkvist P.
        Multiple sclerosis and exposure to organic solvents, investigated by genetic polymorphisms of the GSTM1 and CYP2D6 enzyme system.
        Neurol Sci. 2003 Nov; 24: 248-251
        • Sällstrom T.
        The occurrence and distribution of multiple sclerosis in Sweden.
        Acta Med Scand. 1942; 136 (in German): 1-141
        • Landtblom A.M.
        • Riise T.
        • Boiko A.
        • Söderfeldt B.
        Distribution of multiple sclerosis in Sweden based on mortality and disability compensation statistics.
        Neuroepidemiology. 2002; 21: 167-179
        • Boström I.
        • Callander M.
        • Kurtzke J.F.
        • Landtblom A.M.
        High prevalence of multiple sclerosis in the Swedish county of Värmland.
        Mult Scler. 2009; 15: 1253-1262
      2. Imrell K. Conquering complexity: successful strategies for finding disease genes in multiple sclerosis. Stockholm: Doctoral thesis, 2009. p 19–21, paper III.

        • Callander M.
        • Landtblom A.-M.
        A cluster of multiple sclerosis cases in Lysvik in the Swedish county of Värmland.
        Acta Neurol Scand. 2004; 110: 14-22
        • Sunne kommun
        Lysviks Water Administration, Sunne.
        Pentachlorophenols in the ground water. SWECO VBB AB, 2005 (in Swedish)
        • Guinchard J. Sweden
        Historical and statistical handbook.
        Norsted & Söner, Stockholm: P.A1914
        • Carlquist G.
        • Carlsson J.
        Svensk uppslagsbok. 1–32. Förlagshuset Norden AB, Malmö1959–61 (in Swedish)
        • Edberg R.
        • Arnell A.
        The forest in S county.
        Skogsvardsstyrelsen, Karlstad1973 (in Swedish)
        • Sömme A.
        A geography of Norden.
        William Heinemann Ltd, Denmark, Finland, Iceland, Norway, Sweden. London1961
        • Kungliga Statistiska Centralbyrån
        Statistiska årsbok för Sverige 1915.
        P.A.Norstedt & Söner, Stockholm1915 (in Swedish)
        • National Central Bureau of Statistics
        Statistical abstracts of Sweden 1970.
        own edition, Stockholm1970
        • StatSoft
        Statistica for WindowsTM.
        StatSoft Inc, Tulsa OK1994
        • Landtblom A.M.
        • Riise T.
        • Kurtzke J.F.
        Further considerations on the distribution of multiple sclerosis in Sweden.
        Acta Neurol Scand. 2005; 111: 238-246
        • Lauer K.
        Industrial activity and multiple sclerosis mortality in Austria: an ecological study.
        Mult Scler. 2010; 16: S212
        • Lauer K.
        • Firnhaber W.
        Mortality data of multiple sclerosis in the Federal State of Hesse: geograpic distribution and correlation with socio-geographic varibles.
        Verh Dtsch Ges Neurol. 1989; 5 (in German): 615-618
        • Darmstaedter E.
        The mortality of multiple sclerosis 1975–1995 in the State of Lower Saxony, northern Germany.
        Mult Scler. 2008; 14: S189
        • Howe C.L.
        • Adelson J.D.
        • Rodriguez M.
        Absence of perforin expression confers axonal protection despite demyelination.
        Neurobiol Dis. 2007; 25: 354-359
        • Baron A.
        • Waldman R.
        • Lazdunski M.
        ASIC-like, proton-activated currents in rat hippocampa neurons.
        J Physiol. 2002; 539: 485-494
        • Banna N.R.
        • Jabbur S.J.
        Increased transmitter release induced by convulsant phenols.
        Brain Res. 1970; 20: 471-473
        • McConnachie P.R.
        • Zahalky A.C.
        Immunological consequences of exposure to pentachlorophenol.
        Arch Environ Health. 1991; 46: 249-253
        • Vojdani A.
        • Ghoneum M.
        • Brautbar N.
        Immune alterations associated with exposure to toxic chemicals.
        Toxicol Ind Health. 1992; 8: 239-254
        • Rothbard J.
        Peptides and the cellular immune response.
        Ann Institut Pasteur. 1986; 137E: 518-526
        • Rothbard J.B.
        • Taylor W.R.
        A sequence pattern common to T cell epitopes.
        EMBO J. 1988; 7: 93-100
        • Knowles M.E.
        • Gilbert J.
        • McWeeny D.J.
        Phenols in smoked, cured meats: nitrosation of phenols in liquid smokes and smoked bacon.
        J Sci Food Agr. 1975; 26: 267-276
        • Lauer K.
        Environmental nitrophenols and autoimmunity.
        Mol Immunol. 1990; 27: 697-698