Abstract
Guillain–Barré syndrome (GBS) is an acute immune-mediated disorder of the peripheral
nervous system and a triggering infectious event is often reported in the weeks before
the disease onset. Influenza viruses have been associated with Guillain–Barré syndrome
(GBS), both after infection and, in rare cases, after vaccination. However, GBS has
rarely reported to be a neurological complication of the recent pandemic influenza
A(H1N1) 2009 virus infections. Here we describe the case of a young man, who developed
acute severe motor inflammatory demyelinating polyradiculoneuropathy during influenza
A(H1N1)2009 infection. Peculiar features are the findings of a mutated haemagglutinin
gene (D222E variant), which has never previously been associated with neurological
involvement, and the almost simultaneous appearance of respiratory infectious and
immune-mediated neurological symptoms. Moreover we review the clinical presentation,
laboratory findings and outcome of influenza-related GBS.
Keywords
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Article info
Publication history
Published online: October 14, 2011
Accepted:
August 31,
2011
Received in revised form:
August 30,
2011
Received:
May 16,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
