Abstract
Brain injury from carbon monoxide (CO) poisoning occurs due to tissue hypoxia and
direct CO-mediated histotoxicity. Recently developed susceptibility-weighted imaging
(SWI) is sensitive for the detection of accumulated hemosiderin and iron secondary
to cerebral hemorrhage. Therefore, we hypothesized that SWI may be helpful for identifying
petechial hemorrhagic transformation secondary to acute hypoxic damage during subacute
CO intoxication. Our case series with subacute CO intoxication revealed that the SWIs
of all patients showed low signal intensities in the globus pallidus, representing
the accumulation of iron or calcium secondary to hypoxic damage from acute CO intoxication.
These results suggest that SWI may be a useful MR technique for illustrating brain
damage in subacute delayed CO intoxication.
Keywords
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References
- Carbon monoxide poisoning.N Engl J Med. 1998; 339: 1603-1608
- Experimental carbon monoxide encephalopathy in the primate. II. Clinical aspects, neuropathology, and physiologic correlation.Arch Neurol. 1974; 30: 209-216
- The central nervous system and carbon monoxide poisoning. II. Anatomical study of brain lesions following intoxication with carbon monixide (22 cases).Prog Brain Res. 1967; 24: 31-74
- Pallidoreticular damage in acute carbon monoxide poisoning: diffusion-weighted MR imaging findings.AJNR Am J Neuroradiol. 2005; 26: 1845-1848
- Delayed encephalopathy after acute carbon monoxide intoxication: MR imaging features and distribution of cerebral white matter lesions.Radiology. 1992; 184: 117-122
- Delayed encephalopathy of acute carbon monoxide intoxication: diffusivity of cerebral white matter lesions.AJNR Am J Neuroradiol. 2003; 24: 1592-1597
- Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury.J Neurol Sci. 2009; 277: 147-149
- Susceptibility-weighted imaging: technical aspects and clinical applications, part 1.AJNR Am J Neuroradiol. 2009; 30: 19-30
- Susceptibility-weighted imaging: technical aspects and clinical applications, part 2.AJNR Am J Neuroradiol. 2009; 30: 232-252
- Imaging cerebral microbleeds using susceptibility weighted imaging: one step toward detecting vascular dementia.J Magn Reson Imaging. 2010; 31: 142-148
- MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength.AJNR Am J Neuroradiol. 2009; 30: 338-343
- Haemorrhage detection in brain metastases of lung cancer patients using magnetic resonance imaging.J Int Med Res. 2009; 37: 1139-1144
- Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.Proc Natl Acad Sci U S A. 1998; 95: 316-321
- Energy on demand.Science. 1999; 283: 496-497
- Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification.Neurobiol Dis. 2001; 8: 59-68
- Susceptibility weighted imaging (SWI).Magn Reson Med. 2004; 52: 612-618
- MR appearance of haemorrhage in the brain.Radiology. 1994; 189: 15-26
- Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain.J Magn Reson Imaging. 2007; 26: 256-264
- Identification of calcification with MRI using susceptibility-weighted imaging: a case study.J Magn Reson Imaging. 2009; 29: 177-182
- Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults.J Magn Reson Imaging. 2010; 32: 561-576
- Carbon monoxide intoxication: an updated review.J Neurol Sci. 2007; 262: 122-130
Article info
Publication history
Published online: September 14, 2011
Accepted:
August 23,
2011
Received in revised form:
August 21,
2011
Received:
April 18,
2011
Identification
Copyright
© 2011 Published by Elsevier Inc.
