Abstract
As results from published studies on the association of Cystathionine β Synthase (CBS)
T833C genetic polymorphism with the risk of stroke are inconsistent, we performed
a meta-analysis to summarize the possible association. Eligible studies published
were searched for in PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure
(CNKI), Chinese Biomedical Literature Database (CBM), and the Chinese database, Wanfang.
Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for the
association using fixed- or random-effect model. We identified 10 case–control studies
including 2247 cases and 1813 controls for the present meta-analysis. Significant
associations between CBS T833C genetic polymorphism and risk of stroke were observed
in most genetic models (OR=1.57, 95% CI=1.02–2.41, p=0.039 for TC+CC vs. TT; OR=1.79, 95% CI=1.14–2.82, p=0.012 for CC vs. TT; OR=1.56, 95% CI=1.01–2.40, p=0.044 for TC vs. TT). Moreover, in the subgroup analysis based on ethnicity, significant
associations were observed in most genetic models in Chinese but not in Caucasian.
This meta-analysis provided evidence that CBS T833C genetic polymorphism was associated
with increased risk of stroke, and the C allele probably acts as an important stroke
risk factor.
Keywords
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References
- The top 10 causes of death.Geneva. 2008
- Stroke in China: epidemiology, prevention, and management strategies.Lancet Neurol. 2007; 6: 456-464
- Childhood Thrombophilia Study Group. Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children.Thromb Haemost. 2004; 91: 308-314
- Hyperhomocysteinemia and thrombosis.Hematol Oncol Clin North Am. 2003; 17: 85-102
- Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a multicenter case–control study in China.Stroke. 2003; 34: 2085-2090
- A meta-analysis of cerebrovascular disease and hyperhomocysteinaemia.Scand J Clin Lab Invest. 2000; 60: 491-499
- Mechanisms of homocysteine-induced atherothrombosis.J Thromb Haemost. 2005; 3: 1646-1654
- The human cystathionine β-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms.Genomics. 1998; 52: 312-324
- A 68-bp insertion found in a homocystinuric patient is a common variant and is skipped by alternative splicing of the cystathionine b-synthase mRNA.Am J Hum Genet. 1996; 59: 1391-1393
- Serum homocysteine in patients with patients with cerebral infarction.Zhong Feng Yu Shen Jing Ji Bing Za Zhi. 2003; 20: 295-298
- The correlation between T833C mutation of the cystathionine beta-synthase and cerebral infarction.Zhong Guo Nao Xue Guan Bing Za Zhi. 2006; 3: 31-33
- Relationship between genetic polymorphisms of cystathionine beta synthase and cerebral infarction recurrence in young and adult.Shan Dong Yi Yao. 2010; 50: 7-9
- Genetic mutations of homocysteine metabolism related enzymes in patients with ischemic stroke.Yi Chuan. 2004; 26: 298-302
- Isolated thrombosis due to the cystathionine beta-synthase mutation c.833T>C (1278T).J Inherit Metab Dis. 2003; 26: 509-511
- Association of plasma homocysteine and cystathionine beta-synthase polymorphism with cerebral thrombosis.Di Yi Jun Yi Da Xue Xue Bao. 2005; 25: 351-353
- T833C mutation in cystathionine-beta-synthase gene is not associated with hemorrhagic stroke in Chinese.Gao Xue Ya Za Zhi. 2004; 12: 223-224
- The association between CBS T833C genetic polymorphism and ischemic stroke in Chinese.Shan Dong Yi Yao. 2006; 46: 51-52
- Association between cystathionine-beta synthase gene mutation and ischemic cerebrovascular disease in youths.Zhong Guo Lin Chuang Kang Fu. 2006; 10: 170-172
- Homocysteine level and metabolism in ischemic stroke in the population of Northern Poland.Clin Biochem. 2009; 42: 442-447
- The combination of estimates from different experiments.Biometrics. 1954; 10: 101-129
- Statistical aspects of the analysis of data from retrospective studies of disease.J Natl Cancer Inst. 1959; 22: 719-748
- Meta-analysis in clinical trials.Control Clin Trials. 1986; 7: 177-188
- Quantifying heterogeneity in a meta-analysis.Stat Med. 2002; 21: 1539-1558
- Bias in meta-analysis detected by a simple, graphical test.BMJ. 1997; 315: 629-634
- Publication bias: a problem in interpreting medical data.J R Statist Soc A. 1988; 151: 419-463
- Cystathionine beta-synthase T833C/844ins68 polymorphism and stroke.Neurol India. 2006; 54: 446
- Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.J Biol Chem. 1984; 259: 9508-9513
- A mathematical model of the methionine cycle.J Theor Biol. 2004; 226: 33-43
- Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionine.Am J Physiol. 1988; 255: E322-E331
- Homocysteine and atherothrombosis.N Engl J Med. 1998; 338: 1042-1050
- Homocysteine.Int J Biochem Cell Biol. 2000; 32: 385-389
- Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases.Thromb Res. 2001; 104: 187-195
- Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine b-synthase and A2756G of methionine synthase, with lowered plasma homocysteine levels.Atherosclerosis. 2000; 149: 131-137
- Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population.Atherosclerosis. 1999; 146: 133-140
- Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases.Atherosclerosis. 1999; 143: 163-170
Article info
Publication history
Published online: September 14, 2011
Accepted:
August 22,
2011
Received:
July 13,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
