The clinical diagnosis of amyotrophic lateral sclerosis (ALS) usually takes several months. The delay in diagnosis compromises the effective therapeutic interventions. Therefore, the present study was aimed to develop a statistical model for predicting the risk of ALS at earlier stages for better management of ALS patients.
The study recruited 44 sporadic ALS patients and 29 normal controls. Thirteen different independent variables (predictors) which were believed to be associated with ALS were included in the study. Forward stepwise (likelihood ratio) binary logistic regression was used to find significant variables and probability of disease prediction.
The Hosmer–Lemeshow goodness of fit statistic (χ2=4.379, df=8, p=0.821) indicate the appropriateness of forward stepwise (likelihood ratio) binary logistic regression model. Serum chemokine ligand-2, chemokine ligand-2 mRNA, vascular endothelial growth factor-A mRNA, smoking and alcohol consumption are the independent variables found significant to predict risk of ALS (p<0.05). The current model yielded 93.2% sensitivity and 86.2% specificity with 90.4% overall validity of correct ALS prediction.
Forward stepwise (likelihood ratio) binary logistic regression model is an accurate method to predict ALS in the presence of serum CCL2, CCL2 mRNA, VEGFA mRNA, smoking and alcohol consumption with high sensitivity and specificity. However, bed side diagnostic utility of these variables needs to be validated further in larger ALS cohorts.
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- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.Nature. 1993; 362: 59-62
- Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation.Ann Neurol. 1997; 42: 803-807
- Protein biomarkers for amyotrophic lateral sclerosis.Expert Rev Proteomics. 2008; 5 (Review): 249-262
- Occurrence of PARK2 mutations in a never-smoker population with parkinson's disease in North India.Neuroepidemiology. 2010; 35: 152-159
- Chapman and Hall, 1989 The analysis of binary data. 2nd edition.
- A note on a general definition of the coefficient of determination.Biometrika. 1991; 78: 691-692
- Neuroepidemiology of amyotrophic lateral sclerosis: clues to aetiology and pathogenesis.J Neurol Neurosurg Psychiatry. 1996; 61: 131-137
- A simple model to predict coronary disease in patients undergoing operation for mitral regurgitation.Ann Thorac Surg. 2003; 75: 1820-1825
- FOOD trial collaboration. Feed or ordinary diet. Performance of a statistical model to predict stroke outcome in the context of a large, simple, randomized, controlled trial of feeding.Stroke. 2003; 34: 127-133
- A model to predict the development of mental status changes of unclear cause after liver transplantation.Liver Transpl. 2003; 9: 1312-1319
- Physiologic variables and functional status independently predict COPD hospitalizations and emergency department visits in patients with severe COPD.COPD. 2007; 4: 29-39
- Clinical characteristics and survival pattern of 1,153 patients with amyotrophic lateral sclerosis: experience over 30 years from India.J Neurol Sci. 2008; 272: 60-70
- Onset, natural history and outcome in idiopathic adult motor neuron disease.J Neurol Sci. 1993; 118: 48-55
- Genetics of familial amyotrophic lateral sclerosis.Neurology. 2008; 70: 144-152
- Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.Ann Neurol. 2004; 55: 221-235
- VEGF-A is increased in serum but not in spinal cord from patients with amyotrophic lateral sclerosis.Neuroreport. 2002; 13: 2199-2201
- Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients.J Neuroinflammation. 2011; 8: 47
- Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption.Am J Epidemiol. 2000; 151: 156-163
- Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohorts.Arch Neurol. 2011; 68: 207-213
Published online: September 12, 2011
Accepted: August 11, 2011
Received in revised form: August 9, 2011
Received: April 18, 2011
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.