Abstract
The effects of three types of global ischemia by occlusion of carotid artery on motor
and exploratory behaviors of Gerbils were evaluated by the Activity Cage and Rota
rod tests. Animals were divided based on two surgical criteria: unilateral (UNI) or
bilateral (BIL) carotid occlusion, with (REP) or without (OCL) reperfusion; and their
behavior was evaluated on the fourth (4) or sixth (6) day. There was reduction of
cell number in striatum, motor cortex M1 area, and hippocampal CA1 area in all groups
in comparison to control animals. For M1 area and striatum, the largest reduction
was observed in UNI6, UNI4, and BIL4 groups. Neuronal loss was also observed in CA1
area of BIL4 rodents. There was a decrease in crossings and rearings in all groups
in activity cage test, compared to control. Reperfusion, unilateral and bilateral
occlusion groups showed decrease in crossings. Only the BIL4 showed a decrease of
rearing. In the Rota rod test, except the UNIOCL6, the groups showed a decrease in
the balance in comparison to control. Both groups with REP4 showed a major decrease
in balance. These findings suggest that both unilateral and bilateral carotid occlusions
with reperfusion produce impairments of motor and exploratory behavior.
Keywords
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Article info
Publication history
Published online: August 29, 2011
Accepted:
August 9,
2011
Received in revised form:
August 5,
2011
Received:
May 20,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
