Abstract
Background
Transient ischemic attack (TIA) is a marker of stroke, especially in the early phase
following this event. The aims of this study are to determine the short-term risk
of stroke and to evaluate the independent predictors of stroke in patients with TIA
who are hospitalized within 48 hours after symptom onset.
Methods
During a 36-month period (beginning in November 2007), 3554 patients (mean age: 70.5±13 years; 49.9% female; mean NIHSS score: 1.4±2.5) from 15 hospitals suffering from TIA were prospectively evaluated.
Results
Of the 3554 patients, 43 (1.2%) suffered from stroke during hospitalization (6.5 ±
4.3 days). We identified the following independent predictors for stroke after TIA: male
sex (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.3–5; P=0.008), age≥65 years (OR, 4.7; 95% CI, 1.4–15; P=0.01), hyperlipidemia (OR, 2.4; 95% CI, 1.2–4.8; P=0.015), and dysarthria (OR, 2; 95% CI, 1.1–5.0; P=0.038).
Conclusion
Patient characteristics (male sex, age, and hyperlipidemia) and TIA symptom (dysarthria)
may be useful in defining stroke after TIA in patients who were hospitalized with
TIA.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Incidence of transient ischemic attack in Rochester, Minnesota, 1985–1989.Stroke. 1998; 29: 2109-2113
- Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services.BMJ. 2004; 328: 326-328
- Very early risk of stroke after a first transient ischemic attack.Stroke. 2003; : 34138-34140
- National Stroke Association guidelines for the management of transient ischemic attacks.Ann Neurol. 2006; 60: 301-313
- Definition and evaluation of transient ischemic attack.Stroke. 2009; 40: 2276-2293
- Guidelines for management of ischaemic stroke and transient ischaemic attack 2008.Cerebrovasc Dis. 2008; 25: 457-507
- Concept of supraregional and regional care of stroke patients in Germany.Akt Neurologie. 2000; 27: 101-103
- Recommendations for the establishment of primary stroke centers. Brain Attack Coalition.JAMA. 2000; 283: 3102-3109
- National study on emergency department visits for transient ischemic attack, 1992–2001.Acad Emerg Med. 2006; 13: 666-672
- In-hospital initiation of secondary stroke prevention therapies yields high rates of adherence at follow-up.Stroke. 2004; 35: 2879-2883
- Yield of systematic transcranial Doppler in patients with transient ischemic attack.Ann Neurol. 2010; 68: 9-17
- Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison.Lancet. 2007; 370: 1432-1442
- A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects.Lancet Neurol. 2007; 6: 953-960
- Short-term prognosis after emergency department diagnosis of TIA.JAMA. 2000; 284: 2901-2906
- Prognosis of transient ischemic attacks in the Oxfordshire Community Stroke Project.Stroke. 1990; 21: 848-853
- A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack.Lancet. 2005; 366: 29-36
- Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack.Lancet. 2007; 369: 283-292
Article info
Publication history
Published online: August 29, 2011
Accepted:
August 9,
2011
Received in revised form:
August 5,
2011
Received:
June 9,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
