Abstract
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment for
Parkinson's disease, probably related to sensitization of the mesolimbic dopamine
system. The relationship between dopamine dysregulation syndrome and deep brain stimulation
of the subthalamic nucleus remains unclear.
We report three patients with Parkinson's disease who developed de novo dopamine dysregulation
syndrome after deep brain stimulation of the subthalamic nucleus. We hypothesized
that the combined effect of dopaminergic replacement therapy and deep brain stimulation
on the limbic territory of the subthalamic nucleus could have precipitated the dopamine
dysregulation syndrome in these patients, by inducing hyperstimulation of the mesolimbic
dopamine system. The outcome of postoperative dopamine dysregulation syndrome is poor
despite deep brain stimulation adjustments, attempts to reduce the dose of dopaminergic
drugs and the addition of quetiapine or antidepressants.
Keywords
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Article info
Publication history
Published online: August 29, 2011
Accepted:
August 8,
2011
Received in revised form:
August 5,
2011
Received:
May 26,
2011
Footnotes
☆The authors have no conflict of interest regarding this manuscript.
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
