To evaluate characteristics and mortality related to post-stroke fatigue (PSF).
All surviving stroke patients admitted to the Stroke Unit, Haukeland University Hospital, between February 2006 and November 2008 were sent a postal questionnaire including the Fatigue Severity Scale (FSS), the hospital anxiety and depression scale (HADSD), and the Barthel Index (BI) at least 6 months after stroke onset. Survival among patients returning the questionnaire was determined by November 2009. PSF was defined as FSS score≥5.
Among 377 patients returning the questionnaire, 42.3% had PSF. Logistic regression showed that PSF was independently associated with pre-stroke depression, leucoaraiosis, myocardial infarction, diabetes mellitus, pain, and sleeping disturbances. Mean FSS score was lower among TIA patients than among patients with minor cerebral infarction (patients with BI=100) (P=.002). Cox regression analysis showed mortality to be associated with PSF.
There is a multifactorial basis for PSF suggesting different therapy options. Cerebral lesions may cause PSF in some patients. Post-stroke fatigue is associated with higher mortality.
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- Fatigue after stroke: a major but neglected issue.Cerebrovasc Dis. 2001; 12: 75-81
- Measuring fatigue in patients with Parkinson's disease—the Fatigue Severity Scale.Eur J Neurol. 2002; 9: 595-600
- Fatigue after stroke.Arch Phys Med Rehabil. 1999; 80: 173-178
- Fatigue at long-term follow-up in young adults with cerebral infarction.Cerebrovasc Dis. 2005; 20: 245-250
Tang WK, Chen YK, Mok V, et al. Acute basal ganglia infarcts in poststroke fatigue: an MRI study. J Neurol. 2009
- Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden.Stroke. 2002; 33: 1327-1333
- Interrater reliability of an etiologic classification of ischemic stroke.Stroke. 1995; 26: 46-51
- The measurement of fatigue: a new instrument.J Psychosom Res. 1993; 37: 753-762
- The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus.Arch Neurol. 1989; 46: 1121-1123
- The hospital anxiety and depression scale.Acta Psychiatr Scand. 1983; 67: 361-370
- Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS?.Mult Scler. 2005; 11: 198-202
- Measuring health-related quality of life in adolescents and young adults: Swedish normative data for the SF-36 and the HADS, and the influence of age, gender, and method of administration.Health Qual Life Outcome. 2006; 4: 91
- Validation of the fatigue severity scale in a Swiss cohort.Sleep. 2008; 31: 1601-1607
- Poststroke fatigue: course and its relation to personal and stroke-related factors.Arch Phys Med Rehabil. 2006; 87: 184-188
- Functional outcome in poststroke patients with or without fatigue.Am J Phys Med Rehabil. 2009; 88: 554-558
- Prevalence and predictors of pain and fatigue after stroke: a population-based study.Int J Rehabil Res. 2006; 29: 329-333
- Psychiatric aspects of diabetes mellitus.Br J Psychiatr. 1984; 145: 269-276
- A population-based study of the prevalence of fatigue after transient ischemic attack and minor stroke.Stroke. 2009; 40: 757-761
Published online: August 24, 2011
Accepted: August 2, 2011
Received: February 17, 2011
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.