Abstract
Recently, several studies using transcranial sonography (TCS) have resulted in the
alteration of the mesencephalic midline in patients with depression. We aimed to investigate
and compare sonographic abnormalities in the brainstem raphe (BR) in patients with
Parkinson's disease (PD) and controls, according to presence of depression. Study
participants totaled 61 patients with PD (29 PD without depression, 32 PD with depression)
and 41 controls. Results indicated that decreased BR echogenicity was much higher
in PD patients with depression (PD+D) than in those without depression (PD−D). Of
the 61 PD patients, 32 (52.4%) had depression as diagnosed by psychiatric assessment,
and 13 (17.6%) were excluded, due to insufficient temporal windows. Based on these
results, the use of TCS with respect to the mesencephalic midline may be useful in
detecting depression, a risk factor for the development of PD.
Keywords
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Article info
Publication history
Published online: August 22, 2011
Accepted:
July 30,
2011
Received in revised form:
July 27,
2011
Received:
March 7,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
