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Mesencephalic midline change on transcranial sonography in early Parkinson's disease patients with depression

  • Jung Woo Cho
    Affiliations
    Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
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  • Jong Sam Baik
    Correspondence
    Corresponding author at: Department of Neurology, Sanggye Paik Hospital, Inje University, 761-1, Sanggye 7 dong, No won gu, Seoul, 139-707, Republic of Korea. Tel.: +82 2 950 1090; fax: +82 2 950 1955.
    Affiliations
    Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
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  • Myung Sik Lee
    Affiliations
    Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
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Published:August 22, 2011DOI:https://doi.org/10.1016/j.jns.2011.07.055

      Abstract

      Recently, several studies using transcranial sonography (TCS) have resulted in the alteration of the mesencephalic midline in patients with depression. We aimed to investigate and compare sonographic abnormalities in the brainstem raphe (BR) in patients with Parkinson's disease (PD) and controls, according to presence of depression. Study participants totaled 61 patients with PD (29 PD without depression, 32 PD with depression) and 41 controls. Results indicated that decreased BR echogenicity was much higher in PD patients with depression (PD+D) than in those without depression (PD−D). Of the 61 PD patients, 32 (52.4%) had depression as diagnosed by psychiatric assessment, and 13 (17.6%) were excluded, due to insufficient temporal windows. Based on these results, the use of TCS with respect to the mesencephalic midline may be useful in detecting depression, a risk factor for the development of PD.

      Keywords

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      References

        • Cummings J.L.
        Depression and Parkinson's disease: a review.
        Am J Psychiatry. 1992; 149: 443-454
        • Lieberman A.
        Depression in Parkinson's disease—a review.
        Acta Neurol Scand. 2006; 113: 1-8
        • Walter U.
        • Behnke S.
        • Eyding J.
        • Niehaus L.
        • Postert T.
        • Seidel G.
        • et al.
        Transcranial brain parenchyma sonography in movement disorders: state of art.
        Ultrasound Med Biol. 2007; 22: 15-25
        • Schmidauer C.
        • Sojer M.
        • Seppi K.
        • Stockner H.
        • Hogl B.
        • Biedermann B.
        • et al.
        Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome.
        Ann Neurol. 2005; 58: 630-634
        • Walter U.
        • Niehaus L.
        • Probst T.
        • Benecke R.
        • Meyer B.U.
        • Dressler D.
        Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes.
        Neurology. 2003; 60: 74-77
        • Naumann M.
        • Becker G.
        • Toyka K.V.
        • Supprian T.
        • Reiners K.
        Lenticular nucleus lesion in idiopathic dystonia detected by transcranial sonography.
        Neurology. 1996; 47: 1284-1290
        • Becker T.
        • Becker G.
        • Seufert J.
        • Hofmann E.
        • Lange K.W.
        • Naumann M.
        • et al.
        Parkinson's disease and depression: evidence for an alteration of the basal limbic system detected by transcranial sonography.
        J Neurol Neurosurg Psychiatry. 1997; 63: 590-596
        • Berg D.
        • Supprian T.
        • Hofmann E.
        • Zeiler B.
        • Jager A.
        • Lange K.W.
        • et al.
        Depression in Parkinson's disease: brainstem midline alteration on transcranial sonography and magnetic resonance imaging.
        J Neurol. 1999; 246: 1186-1193
        • Walter U.
        • Dressler D.
        • Wolters A.
        • Probst T.
        • Grossmann A.
        • Benecke R.
        Sonographic discrimination of corticobasal degeneration vs. progressive supranuclear palsy.
        Neurology. 2004; 63: 504-509
        • Walter U.
        • Krolikowski K.
        • Tarnacka B.
        • Benecke R.
        • Czlonkowska A.
        • Dressler D.
        Sonographic detection of basal ganglia lesions in asymptomatic and symptomatic Wilson disease.
        Neurology. 2005; 64: 1726-1732
        • Becker G.
        • Becker T.
        • Struck M.
        • Lindner A.
        • Burzer K.
        • Retz W.
        • et al.
        Reduced echogenicity of brainstem raphe specific to unipolar depression: a transcranial color-coded real-time sonography study.
        Biol Psychiatry. 1995; 38: 180-184
        • Becker G.
        • Struck U.
        • Bogdahn U.
        • Becker T.
        Echogenicity of the brainstem raphe in patients with major depression.
        Psychiatry Res. 1994; 55: 75-84
        • Hughes A.J.
        • Ben-Shlomo Y.
        • Daniel S.E.
        • Lees A.J.
        What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study.
        Neurology. 1992; 42: 1142-1146
        • Schrag A.
        • Barone P.
        • Brown R.G.
        • Leentjens A.F.G.
        • McDonald W.M.
        • Starkstein S.
        • et al.
        Depression rating scales in Parkinson's disease: critique and recommendations.
        Mov Disord. 2007; 22: 1077-1092
        • Berg D.
        • Becker G.
        • Zeiler B.
        • Tucha O.
        • Hofmann E.
        • Preier M.
        • et al.
        Vulnerability of the nigrostriatal system as detected by transcranial ultrasound.
        Neurology. 1999; 53: 1026-1031
        • Walter U.
        • Hoeppner J.
        • Prudente-Morrissey L.
        • Horowski S.
        • Herpertz S.C.
        • Benecke R.
        Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disorders.
        Brain. 2007; 130: 1799-1807
        • Walter U.
        • Prudente-Morrissey L.
        • Herpertz S.C.
        • Benecke R.
        • Hoeppner J.
        Relationship of brainstem raphe echogenicity and clinical findings in depressive states.
        Psychiatry Res. 2007; 155: 67-73
        • Ryu J.H.
        • Lee M.S.
        • Baik J.S.
        Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson's disease.
        Parkinsonism Relat Disord. 2011; 17: 201-203