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Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease

  • Naroa Ibarretxe-Bilbao
    Correspondence
    Corresponding author at: Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Avenida de las Universidades 24, 48007 Bilbao, Spain. Tel.: +34 94 413 90 00x2891.
    Affiliations
    Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Spain

    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain

    Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Spain

    Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Spain
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  • Carme Junque
    Affiliations
    Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Spain

    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain
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  • Maria J. Marti
    Affiliations
    Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Spain

    Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Spain
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  • Eduardo Tolosa
    Affiliations
    Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Spain

    Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Spain
    Search for articles by this author
Published:August 24, 2011DOI:https://doi.org/10.1016/j.jns.2011.07.054

      Abstract

      Cognitive dysfunction occurs at early stages of Parkinson's disease (PD). Initial studies reported that cognitive dysfunction in early PD only affected fronto-striatal circuits, provoking a marked executive dysfunction. Memory impairment in PD was thought to depend on a problem in retrieving stored information, therefore also reflecting a fronto-striatal dysfunction. However, there is increasing structural MRI evidence of medial temporal lobe atrophy in PD, which may be responsible for memory dysfunction. Other neuropsychological functions usually impaired in PD are semantic fluency, visuoperceptual and visuospatial functions, decision-making and recognition of facial emotions; and impairments in these functions are associated with cortical structural changes assessed by MRI. Overall, although the literature on the topic is scarce, there is increasing evidence of brain structural changes, detectable by MRI, which can explain the neuropsychological deficits early in the clinical disease course before dementia develops. In this review, we summarize the papers that have used structural MRI to study the neuroanatomical correlates of cognitive dysfunctions in PD.

      Keywords

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