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Monitoring therapeutic effects in Parkinson's disease by serial imaging of the nigrostriatal dopaminergic pathway

  • Jan Booij
    Correspondence
    Corresponding author at: Department of Nuclear Medicine, F2N, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Tel.: +31 20 5662397; fax: +31 20 5669092.
    Affiliations
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
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  • Henk W. Berendse
    Affiliations
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
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Published:August 16, 2011DOI:https://doi.org/10.1016/j.jns.2011.07.029

      Abstract

      PET and SPECT are very sensitive techniques to detect in-vivo nigrostriatal degeneration in Parkinson's disease, even in the pre-motor phase of the disease. Furthermore, these techniques are able to measure disease progression. However, caution must be used in the interpretation of studies in which therapeutic effects in Parkinson's disease were also monitored by serial imaging of nigrostriatal neurons, as disparity between imaging and clinical outcomes has been reported in several clinical studies.

      Keywords

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