Abstract
Depression is one of the most common non-motor symptoms of Parkinson's disease (PD)
with a large negative impact on the quality of life. Factors such as disease stage,
subtype of PD and gender might play an important role in the prevalence of depression,
but a large study investigating all these factors in a within-subject design is lacking.
Therefore we studied a homogeneous group of 256 Dutch PD patients (60% men, mean age=65.12 (±9.6) years). In total, 36.3% of the subjects had a BDI-score indicative for a minor
depression, while 12.9% had a major depression. Notably, only 8.6% of the minor depressed
patients and 30.3% of the major depressed patients were taking antidepressants. A
higher prevalence of depression was observed in the later stages of the disease. However,
this finding was absent in a smaller subsample after correction for cognitive impairment.
Our data did not show a difference in the prevalence of depression between the motor
subtypes and showed a trend towards higher prevalence of depression in the tremor
dominant group. There was no significant difference in the prevalence of depression
between men and women. We will discuss the relevance of these results in relation
to the findings of other studies.
Keywords
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Article info
Publication history
Published online: August 01, 2011
Accepted:
July 5,
2011
Received in revised form:
June 22,
2011
Received:
March 15,
2011
Footnotes
☆Conflict of interest: None.
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
