Abstract
Social Anxiety Disorder (SAD) is more common among PD patients than in the general
population. This association may be explained by psychosocial mechanisms but it is
also possible that neurobiological mechanism underlying PD can predispose to SAD.
The aim of this study was to investigate a possible dopaminergic mechanism involved
in PD patients with SAD, by correlating striatal dopamine transporter binding potential
(DAT-BP) with intensity of social anxiety symptoms in PD patients using SPECT with
TRODAT-1 as the radiopharmaceutical. Eleven PD patients with generalized SAD and 21
PD patients without SAD were included in this study; groups were matched for age,
gender, disease duration and disease severity. SAD diagnosis was determined according
to DSM IV criteria assessed with SCID-I and social anxiety symptom severity with the
Brief Social Phobia Scale (BSPS). Demographic and clinical data were also collected.
DAT-BP was significantly correlated to scores on BSPS for right putamen (r=0.37, p=0.04), left putamen (r=0.43, p=0.02) and left caudate (r=0.39, p=0.03). No significant correlation was found for the right caudate (r=0.23, p=0.21). This finding may reinforce the hypothesis that dopaminergic dysfunction might
be implicated in the pathogenesis of social anxiety in PD.
Keywords
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Article info
Publication history
Published online: July 25, 2011
Accepted:
June 30,
2011
Received in revised form:
June 15,
2011
Received:
March 15,
2011
Footnotes
☆Disclosures: Authors report no conflicts of interest.
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
