Abstract
Impulse control disorders (ICDs) are increasingly reported as a considerable side-effect
of treatment with dopaminergic medication (both levodopa and dopamine agonists (DA)).
ICDs together with punding are described within the entity of dopamine dysregulation
syndrome along with immediate reward seeking and addictive behaviors. The brain functions
involved in reward processing in general and their modulation by medication can be
characterized by neuropsychological assessments and underlying neurobiology can be
investigated by functional neuroimaging techniques such as functional magnetic resonance
imaging (fMRI) or positron emission tomography (PET). By this approach, functional
changes of brain areas involved in reward processing under short-term or chronic DA
therapy were studied. Functional changes in a network involving striatal–thalamic
loops, key structures of the reward system, together with limbic areas (such as the
amygdala) and the ventral tegmental area could be related to pharmacological alterations
of reward processing by dopaminergic medication. In particular, altered ventral striatal
functioning seems to relate to ICDs such as pathological gambling. A general medication
effect in patients under DA in terms of a sensitization toward ICD could be demonstrated.
A synopsis is given on the applications of functional neuroimaging to investigate
reward processing and the influence of dopaminergic medication.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Parkinson's disease-related disorders in the impulsive–compulsive spectrum.J Neurol. Sep. 2008; 255: 48-56
- Addiction.Annu Rev Psychol. 2003; 54: 25-53
- Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management.CNS Drugs. 2009; 23: 157-170
- Impulse-control disorders in Parkinson's disease.CNS Spectr. Aug. 2008; 13: 690-698
- Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.Arch Neurol. May 2010; 67: 589-595
- Does an imbalance between the dorsal and ventral striatopallidal systems play a role in Tourette's syndrome? A neuronal circuit approach.Brain Dev. Dec. 2003; 25: S3-S14
- Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum.J Neurosci. Mar. 15 2000; 20: 2369-2382
- Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study.Brain. May 2009; 132: 1376-1385
- Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors.Neuron. Jan. 14 2010; 65: 135-142
- Pramipexole modulates the neural network of reward anticipation.Hum Brain Mapp. Jun. 9 2010
- Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey.J Neurophysiol. Nov. 1986; 56: 1439-1461
- Reward signaling by dopamine neurons.Neuroscientist. Aug. 2001; 7: 293-302
- Responses of monkey dopamine neurons during learning of behavioral reactions.J Neurophysiol. Jan. 1992; 67: 145-163
- Prediction error as a linear function of reward probability is coded in human nucleus accumbens.Neuroimage. Jun. 2006; 31: 790-795
- The reward circuit: linking primate anatomy and human imaging.Neuropsychopharmacology. Jan. 2010; 35: 4-26
- Temporal difference models and reward-related learning in the human brain.Neuron. Apr. 24 2003; 38: 329-337
- Changes in brain activity related to eating chocolate: from pleasure to aversion.Brain. Sep. 2001; 124: 1720-1733
- Neural responses to monetary incentives in major depression.Biol Psychiatry. Apr. 1 2008; 63: 686-692
- Linking nucleus accumbens dopamine and blood oxygenation.Psychopharmacol (Berl). Apr. 2007; 191: 813-822
- Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics.Neuroimage. Apr. 1 2007; 35: 787-794
- Pathological gambling is linked to reduced activation of the mesolimbic reward system.Nat Neurosci. Feb. 2005; 8: 147-148
- Dysfunction of ventral striatal reward prediction in schizophrenia.Neuroimage. Jan. 15 2006; 29 ([Clinical Trial Research Support, Non-U.S. Gov't]): 409-416
- Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia.Psychopharmacology. Sep. 2009; 206: 121-132
- Compulsive drug use linked to sensitized ventral striatal dopamine transmission.Ann Neurol. May 2006; 59: 852-858
- Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans.Nature. Aug. 31 2006; 442: 1042-1045
- Dopamine, time, and impulsivity in humans.J Neurosci. Jun. 30 2010; 30: 8888-8896
- Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness.Psychopharmacol (Berl). Feb. 2008; 196: 221-232
- Dopamine agonist increases risk taking but blunts reward-related brain activity.PLoS One. 2008; 3: e2479
- Brain imaging studies in pathological gambling.Curr Psychiatry Rep. Oct. 2010; 12: 418-425
- Dopaminergic modulation of risk-based decision making.Neuropsychopharmacology. Feb. 2009; 34: 681-697
- Influence of dopaminergically mediated reward on somatosensory decision-making.PLoS Biol. Jul. 2009; 7: e1000164
- Decision making under risk condition in patients with Parkinson's disease: a behavioural and fMRI study.Behav Neurol. 2010; 23: 131-143
- Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging.Mov Disord. Jul. 15 2008; 23: 1250-1255
- At-risk for pathological gambling: imaging neural reward processing under chronic dopamine agonists.Brain. Sep. 2009; 132: 2396-2402
- Dopamine agonists and risk: impulse control disorders in Parkinson's; disease.Brain. May 2011; 134: 1438-1446
Article info
Publication history
Published online: July 15, 2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
