Abstract
Hyposmia is highly prevalent in the motor phase of Parkinson's disease (PD) and is
an established pre-motor sign of PD that may precede the onset of motor symptoms by as long as 5 years. The data presented here are part of an ongoing study to determine the relationship
of the olfactory deficit in PD with both motor and non-motor features of the disease. The study population so far includes 96 patients with
a clinical diagnosis of PD (UK PD Society Brain Bank criteria; mean age 64.9 years; mean disease duration 4.8 years). Olfactory testing was performed using the 40-item UPSIT. We analyzed the relationship between UPSIT scores and measures of motor
(disease duration, stage and severity) and non-motor (cognitive function, depression, anxiety and sleep) function. In 60 PD patients,
[123I]FP-CIT SPECT scans were available to assess the relationship between UPSIT scores and
striatal dopamine transporter (DAT) binding. Preliminary analyses revealed correlations
of the olfactory deficit in PD with both motor and non-motor features, as well as with striatal DAT binding. These data suggest that the
olfactory deficit in PD is not stationary by the time the motor phase is entered,
but continues to progress over time. Hyposmia may therefore be useful as a marker
of disease progression, at least in the early disease stages.
Keywords
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Article info
Publication history
Published online: June 27, 2011
Accepted:
June 8,
2011
Received in revised form:
June 7,
2011
Received:
March 16,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
