Abstract
In the last few years it has become clear that impulsivity is a complex behaviour
composed of different domains and dependent on different neural networks. The proposed
pathogenetic mechanisms for the emergence of impulsivity disorders in Parkinson's
Disease (PD) can be broadly separated into three potentially interacting processes:
the contribution of premorbid susceptibility to impulsivity, the contribution of the
disease itself to the behaviour and the potential contribution of therapeutic agents.
Growing evidence suggests that dopamine and the subthalamic nucleus are playing a
certain role in the pathophysiology of different aspects of impulsivity. In this review,
we summarise the main concepts defining various components of impulsivity both in
healthy subjects and patients affected by PD.
Keywords
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Article info
Publication history
Published online: June 20, 2011
Accepted:
June 1,
2011
Received in revised form:
May 30,
2011
Received:
March 11,
2011
Footnotes
☆A.P.S. is supported by a grant from the Canadian Institutes of Health Research (MOP 64423) and Edmond J. Safra Philanthropic Foundation.
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
