Abstract
The accumulation of Lewy pathology (LP) within autonomic nervous system tissues has
received increased attention recently as a possible induction site for Lewy neurodegeneration
and a possible source of biopsy material for biomarkers of early Parkinson's disease
(PD). Here, we describe LP accumulation within various tissues involving peripheral
autonomic nervous system neurons in three PD cases and one case of incidental Lewy
body disease. Findings highlight the value of examining pathology within functional
neuroanatomical systems and particularly the importance of Lewy neurites (LNs) in
the pathophysiology of PD.
Keywords
- Alpha-synuclein
- Auerbach plexus
- Autonomic nervous system
- Axonal
- Brainstem
- Celiac ganglion
- Cognitive dysfunction
- Incidental Lewy body disease
- Lewy bodies/Lewy neurites
- Non-motor symptoms
- Parkinson's disease
- Submandibular gland
- Superior cervical ganglion
- Sympathetic trunk
- Synucleinopathy
- Thyroid gland
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Article info
Publication history
Published online: June 20, 2011
Accepted:
June 1,
2011
Received in revised form:
May 27,
2011
Received:
March 29,
2011
Identification
Copyright
Published by Elsevier Inc.
